Literature DB >> 20638054

Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues.

Yasuaki Mohri1, Tomohiro Umezu, Shizu Hidema, Hayato Tomisawa, Atsushi Akamatsu, Shigeki Kato, Akihiro Nawa, Katsuhiko Nishimori.   

Abstract

Lgr4 is one of the genes identified as novel G protein-coupled receptor genes designated Lgr4-Lgr8, with high homology with FSH receptor, LH receptor, and TSH receptor genes, but studies of Lgr4-mutant mice have suggested that Lgr4 has essential functions in development. This is the first report describing the relationship between the functions of Lgr4 and female reproductive systems.
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20638054     DOI： 10.1016/j.fertnstert.2010.05.050

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  9 in total

1.  LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.

Authors:  Zhiying Yue; Zengjin Yuan; Li Zeng; Ying Wang; Li Lai; Jing Li; Peng Sun; Xiwen Xue; Junyi Qi; Zhengfeng Yang; Yansen Zheng; Yuanzhang Fang; Dali Li; Stefan Siwko; Yi Li; Jian Luo; Mingyao Liu
Journal:  FASEB J       Date:  2017-12-21       Impact factor: 5.191

2.  Lgr4 is a key regulator of prostate development and prostate stem cell differentiation.

Authors:  Weijia Luo; Melissa Rodriguez; Joseph M Valdez; Xinglei Zhu; Kunrong Tan; Dali Li; Stefan Siwko; Li Xin; Mingyao Liu
Journal:  Stem Cells       Date:  2013-11       Impact factor: 6.277

Review 3.  The Role of LGR4 (GPR48) in Normal and Cancer Processes.

Authors:  Alejandro Ordaz-Ramos; Victor Hugo Rosales-Gallegos; Jorge Melendez-Zajgla; Vilma Maldonado; Karla Vazquez-Santillan
Journal:  Int J Mol Sci       Date:  2021-04-29       Impact factor: 5.923

4.  Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.

Authors:  Henriette Poaty; Philippe Coullin; Jean Félix Peko; Philippe Dessen; Ange Lucien Diatta; Alexander Valent; Eric Leguern; Sophie Prévot; Charles Gombé-Mbalawa; Jean-Jacques Candelier; Jean-Yves Picard; Alain Bernheim
Journal:  PLoS One       Date:  2012-01-09       Impact factor: 3.240

5.  Uterine kisspeptin receptor critically regulates epithelial estrogen receptor α transcriptional activity at the time of embryo implantation in a mouse model.

Authors:  Jennifer Schaefer; Angelos G Vilos; George A Vilos; Moshmi Bhattacharya; Andy V Babwah
Journal:  Mol Hum Reprod       Date:  2021-09-29       Impact factor: 4.025

6.  Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse.

Authors:  Vanessa de Oliveira; Jennifer Schaefer; Michele Calder; John P Lydon; Francesco J DeMayo; Moshmi Bhattacharya; Sally Radovick; Andy V Babwah
Journal:  FASEB J       Date:  2019-05-15       Impact factor: 5.834

Review 7.  The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.

Authors:  Wim de Lau; Weng Chuan Peng; Piet Gros; Hans Clevers
Journal:  Genes Dev       Date:  2014-02-15       Impact factor: 11.361

8.  Analysis of LGR4 receptor distribution in human and mouse tissues.

Authors:  Jing Yi; Wei Xiong; Xing Gong; Seth Bellister; Lee M Ellis; Qingyun Liu
Journal:  PLoS One       Date:  2013-10-21       Impact factor: 3.240

9.  Lgr4 in ocular development and glaucoma.

Authors:  Stefan Siwko; Li Lai; Jinsheng Weng; Mingyao Liu
Journal:  J Ophthalmol       Date:  2013-06-05       Impact factor: 1.909
  9 in total

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