Literature DB >> 20637761

Effect of human serum on de-N-acetyl sialic acid epitope expression and antibody activity against N. meningitidis group B.

Becca A Flitter1, Jessica Y Ing, Gregory R Moe.   

Abstract

Antibody-mediated complement-dependent bactericidal activity (BCA) against Neisseria meningitidis (Nm) is correlated with protection against invasive disease. Recently, we showed that murine antibodies elicited by neuraminic acid-containing polysialic acid (NeuPSA) antigens conferred protection against Nm group B (NmB) strains in an infant rat model of meningococcal bacteremia [Moe GR, Bhandari TS, Flitter BA. Vaccines containing de-N-acetyl sialic acid elicit antibodies protective against neisseria meningitidis groups B and C. J Immunol 2009;182(10):6610-7]. However, NeuPSA antibodies did not mediate BCA against NmB strains in vitro despite the presence of NmB-reactive IgG and IgM. Using monoclonal antibodies (mAbs) SEAM 2 and 3, which are reactive with two distinctive NeuPSA epitopes, and an NmB anticapsular mAb, we show that growth in human serum affects expression of NeuPSA epitopes by NmB and is necessary for evaluating anti-NeuPSA functional activity. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20637761      PMCID： PMC2924676          DOI： 10.1016/j.vaccine.2010.06.119

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  29 in total

1.  Differences in surface expression of NspA among Neisseria meningitidis group B strains.

Authors:  G R Moe; S Tan; D M Granoff
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

Review 2.  Development of vaccines against meningococcal disease.

Authors:  Luis Jódar; Ian M Feavers; David Salisbury; Dan M Granoff
Journal:  Lancet       Date:  2002-04-27       Impact factor: 79.321

3.  Sequential immunization with vesicles prepared from heterologous Neisseria meningitidis strains elicits broadly protective serum antibodies to group B strains.

Authors:  Gregory R Moe; Patricia Zuno-Mitchell; Samantha N Hammond; Dan M Granoff
Journal:  Infect Immun       Date:  2002-11       Impact factor: 3.441

4.  Complex of meningococcal group B polysaccharide and type 2 outer membrane protein immunogenic in man.

Authors:  W D Zollinger; R E Mandrell; J M Griffiss; P Altieri; S Berman
Journal:  J Clin Invest       Date:  1979-05       Impact factor: 14.808

5.  Functional activity of anti-Neisserial surface protein A monoclonal antibodies against strains of Neisseria meningitidis serogroup B.

Authors:  G R Moe; P Zuno-Mitchell; S S Lee; A H Lucas; D M Granoff
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

6.  Molecular mimetics of Neisseria meningitidis serogroup B polysaccharide.

Authors:  G R Moe; D M Granoff
Journal:  Int Rev Immunol       Date:  2001       Impact factor: 5.311

7.  Clinical evaluation of a group B meningococcal N-propionylated polysaccharide conjugate vaccine in adult, male volunteers.

Authors:  Joëlle Bruge; Nancy Bouveret-Le Cam; Bernard Danve; Geneviève Rougon; Dominique Schulz
Journal:  Vaccine       Date:  2004-03-12       Impact factor: 3.641

8.  Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity.

Authors:  Jo Anne Welsch; Gregory R Moe; Raffaella Rossi; Jeannette Adu-Bobie; Rino Rappuoli; Dan M Granoff
Journal:  J Infect Dis       Date:  2003-11-19       Impact factor: 5.226

9.  Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity.

Authors:  Joyce S Plested; Jo Anne Welsch; Dan M Granoff
Journal:  Clin Vaccine Immunol       Date:  2009-04-01

10.  Human immunity to the meningococcus. I. The role of humoral antibodies.

Authors:  I Goldschneider; E C Gotschlich; M S Artenstein
Journal:  J Exp Med       Date:  1969-06-01       Impact factor: 14.307
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  6 in total

1.  Resistance of Neisseria meningitidis to human serum depends on T and B cell stimulating protein B.

Authors:  Maike G Müller; Nina E Moe; Phillip Q Richards; Gregory R Moe
Journal:  Infect Immun       Date:  2015-01-12       Impact factor: 3.441

2.  The expression profile of de-N-acetyl polysialic acid (NeuPSA) in normal and diseased human tissue.

Authors:  Taizo A Nakano; Lindsay M Steirer; Gregory R Moe
Journal:  J Biol Chem       Date:  2011-09-26       Impact factor: 5.157

3.  Identification of a phage-encoded Ig-binding protein from invasive Neisseria meningitidis.

Authors:  Maike G Müller; Jessica Y Ing; Mike Kai-Wick Cheng; Becca A Flitter; Gregory R Moe
Journal:  J Immunol       Date:  2013-08-07       Impact factor: 5.422

4.  An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.

Authors:  Lindsay M Steirer; Gregory R Moe
Journal:  PLoS One       Date:  2011-11-09       Impact factor: 3.240

Review 5.  Carbohydrate based meningococcal vaccines: past and present overview.

Authors:  Francesco Berti; Maria Rosaria Romano; Francesca Micoli; Roberto Adamo
Journal:  Glycoconj J       Date:  2021-04-27       Impact factor: 2.916

6.  A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.

Authors:  Gregory R Moe; Lindsay M Steirer; Joshua A Lee; Adarsha Shivakumar; Alejandro D Bolanos
Journal:  J Exp Clin Cancer Res       Date:  2021-09-20
  6 in total

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