| Literature DB >> 20637680 |
Tomoko Ota1, Kazutoshi Ota, Hirofumi Jono, Hiromi Fujimori, Mitsuharu Ueda, Satoru Shinriki, Takanao Sueyoshi, Masanori Shinohara, Yukio Ando.
Abstract
The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC), and pleomorphic adenoma (PA). In addition, we performed immunohistochemistry for CD31 and measured microvessel density (MVD), which is an indicator of angiogenesis. Immunohistochemistry showed that MK protein expression was significantly higher in specimens of malignant SGTs (ACC [P<0.01] and MEC [P<0.001]) than in benign SGT (PA) samples. Furthermore, MVD values tended to be higher in cases that exhibited high expression of MK, which indicated a significant correlation between the degree of MK expression and MVD (P<0.001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20637680 DOI： 10.1016/j.oraloncology.2010.06.004
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337