Literature DB >> 20637529

Design and synthesis of novel isoxazole-based HDAC inhibitors.

Paola Conti1, Lucia Tamborini, Andrea Pinto, Laura Sola, Roberta Ettari, Ciro Mercurio, Carlo De Micheli.   

Abstract

A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn(2+)-binding group in order to check its participation in the coordinating process. 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20637529     DOI： 10.1016/j.ejmech.2010.06.035

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  5 in total

1.  Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6.

Authors:  Mohamed D M Traoré; Vincent Zwick; Claudia A Simões-Pires; Alessandra Nurisso; Mark Issa; Muriel Cuendet; Marjorie Maynadier; Sharon Wein; Henri Vial; Helene Jamet; Yung-Sing Wong
Journal:  ACS Omega       Date:  2017-04-20

Review 2.  An overview of metal-free synthetic routes to isoxazoles: the privileged scaffold.

Authors:  Soumyadip Das; Kaushik Chanda
Journal:  RSC Adv       Date:  2021-10-06       Impact factor: 3.361

3.  New Oxazolo[5,4-d]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research.

Authors:  Aleksandra Sochacka-Ćwikła; Marcin Mączyński; Żaneta Czyżnikowska; Benita Wiatrak; Izabela Jęśkowiak; Albert Czerski; Andrzej Regiec
Journal:  Int J Mol Sci       Date:  2022-10-02       Impact factor: 6.208

4.  Amide-Directed Formation of Five-Coordinate Osmium Alkylidenes from Alkynes.

Authors:  Noelia Casanova; Miguel A Esteruelas; Moisés Gulías; Carmen Larramona; José L Mascareñas; Enrique Oñate
Journal:  Organometallics       Date:  2015-12-31       Impact factor: 3.876

5.  Crystal structure and Hirshfeld surface analysis of (Z)-4-(4-hy-droxy-benzyl-idene)-3-methyl-isoxazol-5(4H)-one.

Authors:  Wissem Zemamouche; Rima Laroun; Noudjoud Hamdouni; Ouarda Brihi; Ali Boudjada; Abdelmadjid Debache
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-06-08
  5 in total

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