| Literature DB >> 20637412 |
Abstract
Actin works within eukaryotic cells to facilitate a variety of cellular processes, which are driven by the assembly of G-actin (monomeric form) into F-actin (fibrous form), and the disassembly of F-actin into G-actin. F-actin adopts multiple conformations, which are specified by interactions with various actin-binding proteins. Knowledge of the multiple conformations of actin is the key for understanding its cellular functions. Recently, we published a refined model for F-actin. In this review, based on this model, we discuss the origin, mechanism, and possible physiological significance of the multiple conformations of F-actin. Copyright 2010 Elsevier Ltd. All rights reserved.Mesh:
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Year: 2010 PMID: 20637412 DOI: 10.1016/j.str.2010.05.009
Source DB: PubMed Journal: Structure ISSN: 0969-2126 Impact factor: 5.006