BACKGROUND: Sleep-disordered breathing is a risk factor for stroke, but its association with subclinical atherosclerosis remains controversial. Snoring and insomnia are frequently comorbid with sleep-disordered breathing and may contribute to stroke. Data on the relationship between snoring and insomnia with atherosclerotic disease are sparse. We investigated the relationship between markers of subclinical atherosclerosis, insomnia, snoring, and carotid intima-media thickness, in the Northern Manhattan Study. METHODS: A group of 1605 participants (mean age 65 +/- 8 years; 40% men; 61% Hispanic, 19% black, 20% white) who had carotid intima-media thickness measurements performed was assessed for self-reported sleep habits. Habitual snoring was defined as self-reported snoring greater than four times per week. Presence of insomnia was based on three items extracted from the Hamilton Rating Scale for Depression. Carotid intima-media thickness was expressed as a mean composite measure of intima-media thickness in the carotid bifurcation, common, and internal carotid artery. Multivariate linear regression models were used to identify associations between snoring, insomnia, and carotid intima-media thickness. RESULTS: Habitual snoring was present in 29% of the subjects and insomnia in 26%. There was a higher prevalence of self-reported snoring (84%) and insomnia (66%) among Hispanics than non-Hispanics. The mean total carotid intima-media thickness was 0.95 +/- 0.09 mm; among those with self-reported snoring was 0.94 +/- 0.09 mm; and among those with insomnia was 0.95 +/- 0.08 mm. After controlling for age, gender, race-ethnicity, body mass index and cardiovascular risk factors, snoring (P=0.986) and insomnia (P=0.829) were not significantly associated with increased carotid intima-media thickness. CONCLUSION: Snoring and insomnia were not significantly associated with subclinical atherosclerosis in this population-based community cohort.
BACKGROUND:Sleep-disordered breathing is a risk factor for stroke, but its association with subclinical atherosclerosis remains controversial. Snoring and insomnia are frequently comorbid with sleep-disordered breathing and may contribute to stroke. Data on the relationship between snoring and insomnia with atherosclerotic disease are sparse. We investigated the relationship between markers of subclinical atherosclerosis, insomnia, snoring, and carotid intima-media thickness, in the Northern Manhattan Study. METHODS: A group of 1605 participants (mean age 65 +/- 8 years; 40% men; 61% Hispanic, 19% black, 20% white) who had carotid intima-media thickness measurements performed was assessed for self-reported sleep habits. Habitual snoring was defined as self-reported snoring greater than four times per week. Presence of insomnia was based on three items extracted from the Hamilton Rating Scale for Depression. Carotid intima-media thickness was expressed as a mean composite measure of intima-media thickness in the carotid bifurcation, common, and internal carotid artery. Multivariate linear regression models were used to identify associations between snoring, insomnia, and carotid intima-media thickness. RESULTS: Habitual snoring was present in 29% of the subjects and insomnia in 26%. There was a higher prevalence of self-reported snoring (84%) and insomnia (66%) among Hispanics than non-Hispanics. The mean total carotid intima-media thickness was 0.95 +/- 0.09 mm; among those with self-reported snoring was 0.94 +/- 0.09 mm; and among those with insomnia was 0.95 +/- 0.08 mm. After controlling for age, gender, race-ethnicity, body mass index and cardiovascular risk factors, snoring (P=0.986) and insomnia (P=0.829) were not significantly associated with increased carotid intima-media thickness. CONCLUSION: Snoring and insomnia were not significantly associated with subclinical atherosclerosis in this population-based community cohort.
Authors: Abu S M Shamsuzzaman; Mikolaj Winnicki; Paola Lanfranchi; Robert Wolk; Tomas Kara; Valentina Accurso; Virend K Somers Journal: Circulation Date: 2002-05-28 Impact factor: 29.690
Authors: Tanja Rundek; Mitchell S Elkind; John Pittman; Bernadette Boden-Albala; Steve Martin; Steve E Humphries; Suh-Hang Hank Juo; Ralph L Sacco Journal: Stroke Date: 2002-05 Impact factor: 7.914
Authors: Bernadette Boden-Albala; Eric T Roberts; Carl Bazil; Yeseon Moon; Mitchell S V Elkind; Tatjana Rundek; Myunghee C Paik; Ralph L Sacco Journal: Circ Cardiovasc Qual Outcomes Date: 2012-07-10
Authors: Sharon A Lee; Terence C Amis; Karen Byth; George Larcos; Kristina Kairaitis; Tracey D Robinson; John R Wheatley Journal: Sleep Date: 2008-09 Impact factor: 5.849
Authors: Jinyoung Kim; Allan I Pack; Barbara J Riegel; Julio A Chirinos; Alexandra Hanlon; Seung Ku Lee; Chol Shin Journal: J Sleep Res Date: 2016-12-06 Impact factor: 3.981
Authors: Oscar H Del Brutto; Robertino M Mera; Ernesto Peñaherrera; Aldo F Costa; Rubén Peñaherrera; Pablo R Castillo Journal: J Clin Sleep Med Date: 2019-08-15 Impact factor: 4.062
Authors: Alberto R Ramos; Chuanhui Dong; Tatjana Rundek; Mitchell S V Elkind; Bernadette Boden-Albala; Ralph L Sacco; Clinton B Wright Journal: J Sleep Res Date: 2014-07-07 Impact factor: 3.981
Authors: Megan R Sands; Diane S Lauderdale; Kiang Liu; Kristen L Knutson; Karen A Matthews; Charles B Eaton; Crystal D Linkletter; Eric B Loucks Journal: Stroke Date: 2012-08-30 Impact factor: 7.914
Authors: Bernadette Boden-Albala; Eric T Roberts; Carl Bazil; Yeseon Moon; Mitchell S V Elkind; Tatjana Rundek; Myunghee C Paik; Ralph L Sacco Journal: Circ Cardiovasc Qual Outcomes Date: 2012-07-10
Authors: Faith S Luyster; Kevin E Kip; Daniel J Buysse; Aryan N Aiyer; Steven E Reis; Patrick J Strollo Journal: Sleep Date: 2014-03-01 Impact factor: 5.849
Authors: Alberto R Ramos; William K Wohlgemuth; Chuanhui Dong; Hannah Gardener; Clinton B Wright; Bernadette Boden-Albala; Mitchel S V Elkind; Ralph L Sacco; Tatjana Rundek Journal: Neuroepidemiology Date: 2011-11-26 Impact factor: 3.282