Literature DB >> 20635432

Protein PTMs: post-translational modifications or pesky trouble makers?

Ralph A Bradshaw1, Katalin F Medzihradszky, Robert J Chalkley.   

Abstract

Analysis of protein post-translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results, consequences of unreliable data and what is needed to be done to improve the situation.
Copyright © 2010 John Wiley & Sons, Ltd.

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Year:  2010        PMID： 20635432      PMCID： PMC3133960          DOI： 10.1002/jms.1786

Source DB:  PubMed          Journal:  J Mass Spectrom        ISSN： 1076-5174            Impact factor:   1.982


  3 in total

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Authors:  A L Burlingame; Xin Zhang; Robert J Chalkley
Journal:  Methods       Date:  2005-08       Impact factor: 3.608

Review 2.  Characterization of histones and their post-translational modifications by mass spectrometry.

Authors:  Benjamin A Garcia; Jeffrey Shabanowitz; Donald F Hunt
Journal:  Curr Opin Chem Biol       Date:  2006-12-06       Impact factor: 8.822

3.  Extent of modifications in human proteome samples and their effect on dynamic range of analysis in shotgun proteomics.

Authors:  Michael L Nielsen; Mikhail M Savitski; Roman A Zubarev
Journal:  Mol Cell Proteomics       Date:  2006-10-02       Impact factor: 5.911
  3 in total
  8 in total

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Authors:  Jordane Biarc; Robert J Chalkley; A L Burlingame; Ralph A Bradshaw
Journal:  Mol Cell Proteomics       Date:  2011-10-25       Impact factor: 5.911

2.  Modification site localization scoring integrated into a search engine.

Authors:  Peter R Baker; Jonathan C Trinidad; Robert J Chalkley
Journal:  Mol Cell Proteomics       Date:  2011-04-13       Impact factor: 5.911

3.  Subcellular Fractionation to Demonstrate Activation of Intrinsic Apoptotic Pathway.

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Review 4.  Receptor tyrosine kinase signaling--a proteomic perspective.

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5.  Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models.

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Journal:  Metab Brain Dis       Date:  2011-11-15       Impact factor: 3.584

6.  PHOSIDA 2011: the posttranslational modification database.

Authors:  Florian Gnad; Jeremy Gunawardena; Matthias Mann
Journal:  Nucleic Acids Res       Date:  2010-11-16       Impact factor: 16.971

7.  PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse.

Authors:  Peter V Hornbeck; Jon M Kornhauser; Sasha Tkachev; Bin Zhang; Elzbieta Skrzypek; Beth Murray; Vaughan Latham; Michael Sullivan
Journal:  Nucleic Acids Res       Date:  2011-12-01       Impact factor: 16.971

8.  Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.

Authors:  Meaghan Morris; Giselle M Knudsen; Sumihiro Maeda; Jonathan C Trinidad; Alexandra Ioanoviciu; Alma L Burlingame; Lennart Mucke
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  8 in total

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