OBJECTIVE: 2-deoxy-2-[¹⁸F]fluoro-D-glucose positron emission tomography/computed tomography ([¹⁸F] FDG PET/CT) has become an established imaging tool in oncology and is now emerging in the field of infectious disease. The aim of this study is to assess the value of fluorine [¹⁸F] FDG PET/CT in the investigation of patients with fever of unknown origin (FUO). METHODS: [¹⁸F] FDG PET/CT scans and clinical data of 12 patients were reviewed. These patients met the revised definition criteria of FUO (febrile illness of greater than 3 weeks duration, temperature greater than 38.3°C and no diagnosis after at least 3 days of in-patient investigation or 2 weeks of outpatient investigation). A retrospective analysis of our local database was performed and evaluated for the diagnostic contribution of [¹⁸F] FDG PET/CT scans. RESULTS: An infective cause of the FUO was found in four (33.3%) patients, a neoplasm in two (16.7%) patients, non-infectious inflammatory disease or autoimmune in one (8.3%) patient. A definitive causative agent could not be found in five (41.7%) patients despite extensive investigations.In all, five (41.6%) patients had a PET/CT scan that was abnormal and was deemed 'helpful' as part of the investigation that pointed to the final diagnosis. Two (16.7%) patients had abnormal scans, which were deemed 'not-helpful' for the final diagnosis. CONCLUSION: [¹⁸F] FDG PET/CT can be helpful in some patients with FUO. This study adds value to the limited data published so far on this subject.
OBJECTIVE: 2-deoxy-2-[¹⁸F]fluoro-D-glucose positron emission tomography/computed tomography ([¹⁸F] FDG PET/CT) has become an established imaging tool in oncology and is now emerging in the field of infectious disease. The aim of this study is to assess the value of fluorine [¹⁸F] FDG PET/CT in the investigation of patients with fever of unknown origin (FUO). METHODS: [¹⁸F] FDG PET/CT scans and clinical data of 12 patients were reviewed. These patients met the revised definition criteria of FUO (febrile illness of greater than 3 weeks duration, temperature greater than 38.3°C and no diagnosis after at least 3 days of in-patient investigation or 2 weeks of outpatient investigation). A retrospective analysis of our local database was performed and evaluated for the diagnostic contribution of [¹⁸F] FDG PET/CT scans. RESULTS: An infective cause of the FUO was found in four (33.3%) patients, a neoplasm in two (16.7%) patients, non-infectious inflammatory disease or autoimmune in one (8.3%) patient. A definitive causative agent could not be found in five (41.7%) patients despite extensive investigations.In all, five (41.6%) patients had a PET/CT scan that was abnormal and was deemed 'helpful' as part of the investigation that pointed to the final diagnosis. Two (16.7%) patients had abnormal scans, which were deemed 'not-helpful' for the final diagnosis. CONCLUSION: [¹⁸F] FDG PET/CT can be helpful in some patients with FUO. This study adds value to the limited data published so far on this subject.
Authors: Gijsbert J Blokhuis; Chantal P Bleeker-Rovers; Marije G Diender; Wim J G Oyen; Jos M Th Draaisma; Lioe-Fee de Geus-Oei Journal: Eur J Nucl Med Mol Imaging Date: 2014-05-29 Impact factor: 9.236
Authors: Hussein Mahajna; Keren Vaknin; Jennifer Ben Shimol; Abdulla Watad; Arsalan Abu-Much; Naim Mahroum; Ora Shovman; Yehuda Shoenfeld; Howard Amital; Tima Davidson Journal: Int J Environ Res Public Health Date: 2021-05-18 Impact factor: 3.390