OBJECTIVES: To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK. DESIGN: Observational study. METHODS: MSM diagnosed with HIV-1 infection from 1980-2007, with HIV genotype held in the UK HIV Drug Resistance Database were identified. Protease and reverse transcriptase sequences were collected and viral clade determined using the REGA algorithm. Associations between demographic variables and subtype were analysed using logistic regression. RESULTS: The prevalence of non-B HIV-1 infection amongst MSM in the UK was 5.4% (437/8058). In the UK this increased with year of diagnosis from pre1996 to 2002, and has subsequently remained relatively stable at around 7-9% after 2002, with a recent increase in 2007 to 13%. Multivariate analysis showed that acquisition of non-B HIV-1 infection was independently associated with later year of HIV diagnosis (P < 0.001), black ethnicity (P < 0.001) and non-European country of birth (P = 0.01). Age was also associated with subtype with individuals aged 25-39 years being less likely to have non-B virus than those aged less than 25 years (P = 0.01). Restricting the analysis to white men born in the UK, the association between subtype and year of diagnosis remained statistically significant (P < 0.001), as did the association with age (P < 0.001). DISCUSSION: The number of MSM in the UK infected with non-B clade HIV-1 is increasing, suggesting that the sociodemographic boundaries between HIV-1 viral subtypes globally are diminishing. Should viral subtypes be relevant to clinical disease progression or vaccine design, the changing pattern of distribution will need to be taken into account.
OBJECTIVES: To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK. DESIGN: Observational study. METHODS: MSM diagnosed with HIV-1 infection from 1980-2007, with HIV genotype held in the UK HIV Drug Resistance Database were identified. Protease and reverse transcriptase sequences were collected and viral clade determined using the REGA algorithm. Associations between demographic variables and subtype were analysed using logistic regression. RESULTS: The prevalence of non-B HIV-1 infection amongst MSM in the UK was 5.4% (437/8058). In the UK this increased with year of diagnosis from pre1996 to 2002, and has subsequently remained relatively stable at around 7-9% after 2002, with a recent increase in 2007 to 13%. Multivariate analysis showed that acquisition of non-B HIV-1 infection was independently associated with later year of HIV diagnosis (P < 0.001), black ethnicity (P < 0.001) and non-European country of birth (P = 0.01). Age was also associated with subtype with individuals aged 25-39 years being less likely to have non-B virus than those aged less than 25 years (P = 0.01). Restricting the analysis to white men born in the UK, the association between subtype and year of diagnosis remained statistically significant (P < 0.001), as did the association with age (P < 0.001). DISCUSSION: The number of MSM in the UK infected with non-B clade HIV-1 is increasing, suggesting that the sociodemographic boundaries between HIV-1 viral subtypes globally are diminishing. Should viral subtypes be relevant to clinical disease progression or vaccine design, the changing pattern of distribution will need to be taken into account.
Authors: Fransje A Koning; Anjna Badhan; Simon Shaw; Martin Fisher; Jean L Mbisa; Patricia A Cane Journal: AIDS Res Hum Retroviruses Date: 2013-04-18 Impact factor: 2.205
Authors: Ana B Abecasis; Annemarie M J Wensing; Dimitris Paraskevis; Jurgen Vercauteren; Kristof Theys; David A M C Van de Vijver; Jan Albert; Birgitta Asjö; Claudia Balotta; Danail Beshkov; Ricardo J Camacho; Bonaventura Clotet; Cillian De Gascun; Algis Griskevicius; Zehava Grossman; Osamah Hamouda; Andrzej Horban; Tatjana Kolupajeva; Klaus Korn; Leon G Kostrikis; Claudia Kücherer; Kirsi Liitsola; Marek Linka; Claus Nielsen; Dan Otelea; Roger Paredes; Mario Poljak; Elisabeth Puchhammer-Stöckl; Jean-Claude Schmit; Anders Sönnerborg; Danika Stanekova; Maja Stanojevic; Daniel Struck; Charles A B Boucher; Anne-Mieke Vandamme Journal: Retrovirology Date: 2013-01-14 Impact factor: 4.602