| Literature DB >> 20634068 |
Matthew O Duffey1, Ruth Adams, Christopher Blackburn, Ryan W Chau, Susan Chen, Katherine M Galvin, Khristofer Garcia, Alexandra E Gould, Paul D Greenspan, Sean Harrison, Shih-Chung Huang, Mi-Sook Kim, Bheemashankar Kulkarni, Steven Langston, Jane X Liu, Li-Ting Ma, Saurabh Menon, Masayuki Nagayoshi, R Scott Rowland, Tricia J Vos, Tianlin Xu, Johnny J Yang, Shaoxia Yu, Qin Zhang.
Abstract
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Determination of the pharmacokinetic properties of selected inhibitors is also reported. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20634068 DOI： 10.1016/j.bmcl.2010.06.113
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823