OBJECTIVE: Maternal toxoplasmosis infection acquired during pregnancy carries significant risk of fetal damage. We aimed to assess the long-term outcome of children and young adults with congenital toxoplasmosis diagnosed and treated in utero. STUDY DESIGN: This was a 20 year prospective study (1985-2005). All mothers received spiramycin, alone or associated with pyrimethamine-sulfadoxine, and underwent amniocentesis and monthly ultrasound screening. Infected children were followed every 3-6 months. RESULTS: Of 666 liveborn children (676 mothers), 112 (17%) had congenital toxoplasmosis. Among these, 107 were followed up for 12-250 months: 79 were asymptomatic (74%) and 28 had chorioretinitis (26%). Only 1 child had a serious neurological involvement. CONCLUSION: The percentage of chorioretinitis in treated children depends on length of follow-up, but this complication occurs mainly before the age of 5 years and almost always before the age of 10 years. Visual impairment was infrequently severe, and outcome appears consistently good. Long-term follow-up is recommended to monitor ocular and neurological prognosis, whatever the practical difficulties.
OBJECTIVE:Maternal toxoplasmosis infection acquired during pregnancy carries significant risk of fetal damage. We aimed to assess the long-term outcome of children and young adults with congenital toxoplasmosis diagnosed and treated in utero. STUDY DESIGN: This was a 20 year prospective study (1985-2005). All mothers received spiramycin, alone or associated with pyrimethamine-sulfadoxine, and underwent amniocentesis and monthly ultrasound screening. Infected children were followed every 3-6 months. RESULTS: Of 666 liveborn children (676 mothers), 112 (17%) had congenital toxoplasmosis. Among these, 107 were followed up for 12-250 months: 79 were asymptomatic (74%) and 28 had chorioretinitis (26%). Only 1 child had a serious neurological involvement. CONCLUSION: The percentage of chorioretinitis in treated children depends on length of follow-up, but this complication occurs mainly before the age of 5 years and almost always before the age of 10 years. Visual impairment was infrequently severe, and outcome appears consistently good. Long-term follow-up is recommended to monitor ocular and neurological prognosis, whatever the practical difficulties.
Authors: H Fricker-Hidalgo; C L'Ollivier; C Bosson; S Imbert; S Bailly; C Dard; R Piarroux; L Paris; H Pelloux Journal: Eur J Clin Microbiol Infect Dis Date: 2016-12-19 Impact factor: 3.267
Authors: Marisa N Spann; Andre Sourander; Heljä-Marja Surcel; Susanna Hinkka-Yli-Salomäki; Alan S Brown Journal: Autism Res Date: 2016-11-22 Impact factor: 5.216
Authors: H Fricker-Hidalgo; B Cimon; C Chemla; M L Darde; L Delhaes; C L'ollivier; N Godineau; S Houze; L Paris; D Quinio; F Robert-Gangneux; O Villard; I Villena; E Candolfi; H Pelloux Journal: J Clin Microbiol Date: 2013-04-24 Impact factor: 5.948