BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. OBJECTIVE: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. METHODS: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. RESULTS: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. CONCLUSIONS: EEG points provide a useful way to optimally identify DLPFC.
BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols. OBJECTIVE: The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies. METHODS: Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established. RESULTS: The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex. CONCLUSIONS: EEG points provide a useful way to optimally identify DLPFC.
Authors: Angel V Peterchev; Timothy A Wagner; Pedro C Miranda; Michael A Nitsche; Walter Paulus; Sarah H Lisanby; Alvaro Pascual-Leone; Marom Bikson Journal: Brain Stimul Date: 2011-11-01 Impact factor: 8.955
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