Literature DB >> 20633143

The orexin system: roles in sleep/wake regulation.

Takeshi Sakurai1, Michihiro Mieda, Natsuko Tsujino.   

Abstract

The neuropeptides orexin A and orexin B, produced in hypothalamic neurons, are critical regulators of sleep/wake states. Deficiency of orexin signaling results in narcoleptic phenotype in humans, dogs, and rodents. Recently, accumulating evidence has indicated that the orexin system regulates sleep and wakefulness through interactions with neuronal systems that are closely related with emotion, reward, and energy homeostasis. In this review, we will discuss the current understanding of the physiology of the orexin system especially focusing on its roles in the regulation of sleep/wakefulness states.

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Year:  2010        PMID： 20633143     DOI： 10.1111/j.1749-6632.2010.05513.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  54 in total

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5.  Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area.

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Review 7.  Olfaction under metabolic influences.

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Review 8.  Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

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Journal:  ILAR J       Date:  2012

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Authors:  Yan Rao; Yann S Mineur; Geliang Gan; Alex Hanxiang Wang; Zhong-Wu Liu; Xinyuan Wu; Shigetomo Suyama; Luis de Lecea; Tamas L Horvath; Marina R Picciotto; Xiao-Bing Gao
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