Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ghrelin: more than endogenous growth hormone secretagogue.

Literature DB >> 20633142

Ghrelin: more than endogenous growth hormone secretagogue.

Abstract

Since its discovery 10 years ago, intensive research has been performed on ghrelin. The significance of ghrelin as a growth hormone-releasing hormone, appetite regulator, energy conservator, and sympathetic nerve suppressor has now been well established. In this review, we summarize recent topics on ghrelin, such as the processing protease of the ghrelin precursor, ghrelin O-acyl transaferase, ghrelin knockout and transgenic mice, and the molecular mechanism of ghrelin's orexigenesis.

Entities: Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20633142 DOI： 10.1111/j.1749-6632.2010.05516.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

Keyword Cloud
Cited

27 in total

1. Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

Authors: Sophie Mary; Marjorie Damian; Maxime Louet; Nicolas Floquet; Jean-Alain Fehrentz; Jacky Marie; Jean Martinez; Jean-Louis Banères
Journal: Proc Natl Acad Sci U S A Date: 2012-05-09 Impact factor: 11.205

2. Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.

Authors: Sophie Mary; Jean-Alain Fehrentz; Marjorie Damian; Gérald Gaibelet; Hélène Orcel; Pascal Verdié; Bernard Mouillac; Jean Martinez; Jacky Marie; Jean-Louis Banères
Journal: J Biol Chem Date: 2013-07-09 Impact factor: 5.157

Ghrelin: more than endogenous growth hormone secretagogue.

1. Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

2. Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.

3. Circulating ghrelin and GLP-1 are not affected by habitual diet.

Review 4. G protein-coupled receptor deorphanizations.

5. Ghrelin inhibits visceral afferent activation of catecholamine neurons in the solitary tract nucleus.

6. Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor.

7. Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson's Disease Model Mice.

8. Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia.

9. Distribution and co-expression patterns of specific cell markers of enteroendocrine cells in pig gastric epithelium.

10. Higher postprandial serum ghrelin among African-American girls before puberty.