Literature DB >> 20633137

Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats.

Hiroko Tsukamura1, Tamami Homma, Junko Tomikawa, Yoshihisa Uenoyama, Kei-ichiro Maeda.   

Abstract

The brain mechanism regulating GnRH/luteinizing hormone (LH) release is sexually differentiated in rodents. Estrogen induces a GnRH/LH surge in females but not in males. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) have been reported to be sexually dimorphic and suggested to be involved in the GnRH/LH surge generation. Neonatal testicular androgen may cause the reduction of AVPV kisspeptin expression and a lack of LH surge in male rats. Thus, it is plausible that perinatal testicular androgen causes defeminization of the AVPV kisspeptin system, resulting in the loss of the surge system in male rats.

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Year:  2010        PMID： 20633137     DOI： 10.1111/j.1749-6632.2010.05645.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  9 in total

Review 1.  Organizational and activational effects of sex steroids on kisspeptin neuron development.

Authors:  Matthew C Poling; Alexander S Kauffman
Journal:  Front Neuroendocrinol       Date:  2012-06-19       Impact factor: 8.606

2.  Morphological and functional evidence for sexual dimorphism in neurokinin B signalling in the retrochiasmatic area of sheep.

Authors:  Justin A Lopez; Elizabeth C Bowdridge; Richard B McCosh; Michelle N Bedenbaugh; Ashley N Lindo; Makayla Metzger; Megan Haller; Michael N Lehman; Stanley M Hileman; Robert L Goodman
Journal:  J Neuroendocrinol       Date:  2020-06-22       Impact factor: 3.627

3.  Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator.

Authors:  Mayuko Nagae; Yoshihisa Uenoyama; Saki Okamoto; Hitomi Tsuchida; Kana Ikegami; Teppei Goto; Sutisa Majarune; Sho Nakamura; Makoto Sanbo; Masumi Hirabayashi; Kenta Kobayashi; Naoko Inoue; Hiroko Tsukamura
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-02       Impact factor: 11.205

Review 4.  The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction.

Authors:  Qinying Xie; Yafei Kang; Chenlu Zhang; Ye Xie; Chuxiong Wang; Jiang Liu; Caiqian Yu; Hu Zhao; Donghui Huang
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-28       Impact factor: 6.055

Review 5.  Kisspeptin neurons from mice to men: similarities and differences.

Authors:  Robert L Goodman; Michael N Lehman
Journal:  Endocrinology       Date:  2012-09-18       Impact factor: 4.736

6.  Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice.

Authors:  Kana Ikegami; Teppei Goto; Sho Nakamura; Youki Watanabe; Arisa Sugimoto; Sutisa Majarune; Kei Horihata; Mayuko Nagae; Junko Tomikawa; Takuya Imamura; Makoto Sanbo; Masumi Hirabayashi; Naoko Inoue; Kei-Ichiro Maeda; Hiroko Tsukamura; Yoshihisa Uenoyama
Journal:  J Reprod Dev       Date:  2020-04-20       Impact factor: 2.214

7.  Microarray analysis of perinatal-estrogen-induced changes in gene expression related to brain sexual differentiation in mice.

Authors:  Mototsugu Sakakibara; Yoshihisa Uenoyama; Shiori Minabe; Youki Watanabe; Chikaya Deura; Sho Nakamura; Genki Suzuki; Kei-ichiro Maeda; Hiroko Tsukamura
Journal:  PLoS One       Date:  2013-11-04       Impact factor: 3.240

8.  Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents.

Authors:  Kei Horihata; Naoko Inoue; Yoshihisa Uenoyama; Kei-Ichiro Maeda; Hiroko Tsukamura
Journal:  J Reprod Dev       Date:  2020-01-19       Impact factor: 2.214

Review 9.  Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction.

Authors:  Yoshihisa Uenoyama; Mayuko Nagae; Hitomi Tsuchida; Naoko Inoue; Hiroko Tsukamura
Journal:  Front Endocrinol (Lausanne)       Date:  2021-09-09       Impact factor: 5.555
  9 in total

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