Jun-Guo Liu1, Yi-Jun Wang, Zhi Du. 1. Department of Hepatobiliary Surgery, Third Central Hospital, Tianjin 300170, China.
Abstract
AIM: To evaluate survival and recurrence after radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) using a meta-analysis. METHODS: Literature on RFA vs surgical resection for the treatment of small HCC published between January 1990 and December 2008 was retrieved. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. A fixed or random effect model was established to collect the data. RESULTS: The differences in overall survival at 1-year, 3-years and at end of follow-up were not statistically significant between the RFA and surgery groups (P > 0.05). There were no differences in 1-year and 3-year recurrences between the RFA and surgery groups (P > 0.05). However, recurrence in the RFA group was lower than that in the surgery group up to the end of follow-up (P = 0.03). Survival was not significantly different. There was a significant difference in recurrences at the end of follow-up after RFA compared with surgical resection. CONCLUSION: RFA did not decrease the number of overall recurrences, and had no effect on survival when compared with surgical resection in a selected group of patients.
AIM: To evaluate survival and recurrence after radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (HCC) using a meta-analysis. METHODS: Literature on RFA vs surgical resection for the treatment of small HCC published between January 1990 and December 2008 was retrieved. A meta-analysis was conducted to estimate pooled survival and recurrence ratios. A fixed or random effect model was established to collect the data. RESULTS: The differences in overall survival at 1-year, 3-years and at end of follow-up were not statistically significant between the RFA and surgery groups (P > 0.05). There were no differences in 1-year and 3-year recurrences between the RFA and surgery groups (P > 0.05). However, recurrence in the RFA group was lower than that in the surgery group up to the end of follow-up (P = 0.03). Survival was not significantly different. There was a significant difference in recurrences at the end of follow-up after RFA compared with surgical resection. CONCLUSION: RFA did not decrease the number of overall recurrences, and had no effect on survival when compared with surgical resection in a selected group of patients.
Authors: G J Netto; B Altrabulsi; N Katabi; P Martin; K Burt; M Levy; E Sanchez; D L Watkins; L Jennings; G Klintmalm; R Goldstein Journal: Liver Int Date: 2006-08 Impact factor: 5.828
Authors: Lisette T Hoekstra; Matthanja Bieze; Olivier R C Busch; Dirk J Gouma; Thomas M van Gulik Journal: Surg Endosc Date: 2012-10-06 Impact factor: 4.584