| Literature DB >> 20632063 |
Chanhyok Sakurai-Chin1, Yoshifumi Ubara, Tatsuya Suwabe, Junichi Hoshino, Tomoki Yonaha, Eiko Hasegawa, Keiichi Sumida, Rikako Hiramatsu, Masayuki Yamanouchi, Noriko Hayami, Junji Yamauchi, Naoyuki Tominaga, Naoki Sawa, Fumi Takemoto, Kazuhiro Masuoka, Kenmei Takaichi, Kenichi Oohashi.
Abstract
A 45-year-old Japanese woman had been diagnosed with monoclonal gammopathy of undetermined significance (MGUS) featuring urinary Bence-Jones protein of the lambda type (BJP-lambda) for 11 years. She then developed eyelid purpura, dyspnea, and flank pain. Abdominal CT scans revealed renal infarction. Biopsy of the kidney, heart, jejunum, and skin demonstrated amyloid deposits in the vessel walls, but not in the glomeruli. She was diagnosed as having AL amyloidosis with IgD-lambda monoclonal gammopathy and BJP-lambda. Autologous stem cell transplantation (SCT) was done after chemotherapy with vincristine, daunorubicin, dexamethasone (VAD), and high-dose melphalan (HDM). This reduced the IgD level from 156 to 0.1 mg/dL, along with the disappearance of BJP, despite cerebral infarction during chemotherapy. We recommend SCT for patients with IgD-associated AL amyloidosis.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20632063 DOI： 10.1007/s10157-010-0311-2
Source DB: PubMed Journal: Clin Exp Nephrol ISSN： 1342-1751 Impact factor: 2.801