| Literature DB >> 20630802 |
Simona Sivori1, Michela Falco, Lorenzo Moretta, Alessandro Moretta.
Abstract
Killer Ig-like receptors (KIRs) are human natural killer (NK) receptors that recognize allotypic determinants of human leukocyte antigen (HLA) class I. Inhibitory KIRs discriminate normal cells from tumour or virus-infected cells that have lost or reduced HLA class I expression. Donor NK cell "alloeffector" responses are exploited in haploidentical haematopoietic stem cell transplantation to treat leukaemia. NK cells also express several toll-like receptors (TLRs) that increase NK cell cytotoxicity and cytokine release in response to ligands. Surprisingly, KIR3DL2 binds the TLR ligand CpG-oligodexynucleotides, and together, they are co-internalized and translocated to TLR9-rich early endosomes. This novel KIR-associated function offers clues to understanding the NK cell response to microbial infection, and extends the role played by KIRs in immune defence. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20630802 DOI： 10.1016/j.it.2010.05.007
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687