| Literature DB >> 20630771 |
Rita Vicente1, Louise Swainson, Sophie Marty-Grès, Stéphanie C De Barros, Sandrina Kinet, Valérie S Zimmermann, Naomi Taylor.
Abstract
The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID: 20630771 PMCID: PMC2992869 DOI: 10.1016/j.smim.2010.04.016
Source DB: PubMed Journal: Semin Immunol ISSN: 1044-5323 Impact factor: 11.130