Literature DB >> 20630503

Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells.

JongYeob Choi1, MinWha Jo, EunYoung Lee, DooSeok Choi.   

Abstract

This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20630503     DOI： 10.1016/j.fertnstert.2010.06.006

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  34 in total

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