Strategies for noninvasive demineralized tissue repair.

This article provides a state-of-the-art overview of clinically relevant evidence regarding effective, noninvasive management strategies to prevent, arrest, and remineralize caries lesions. With the rapidly increasing knowledge about oral biofilms and the process of caries in itself, the profession is embarking on new strategies. This is an exciting time, with several promising new agents and novel treatment modalities at the horizon to prevent and manage caries lesions. Some are already available in clinical practice. Studies, however, have yet to show conclusive evidence of clinical efficacy. None have shown to be more effective than fluoride and protection by sealant. Copyright 2010 Elsevier Inc. All rights reserved.