Literature DB >> 20630039

Allelic diversity of the MHC class II DRB genes in brown bears (Ursus arctos) and a comparison of DRB sequences within the family Ursidae.

N Goda1, T Mano, P Kosintsev, A Vorobiev, R Masuda.   

Abstract

The allelic diversity of the DRB locus in major histocompatibility complex (MHC) genes was analyzed in the brown bear (Ursus arctos) from the Hokkaido Island of Japan, Siberia, and Kodiak of Alaska. Nineteen alleles of the DRB exon 2 were identified from a total of 38 individuals of U. arctos and were highly polymorphic. Comparisons of non-synonymous and synonymous substitutions in the antigen-binding sites of deduced amino acid sequences indicated evidence for balancing selection on the bear DRB locus. The phylogenetic analysis of the DRB alleles among three genera (Ursus, Tremarctos, and Ailuropoda) in the family Ursidae revealed that DRB allelic lineages were not separated according to species. This strongly shows trans-species persistence of DRB alleles within the Ursidae.
© 2010 John Wiley & Sons A/S.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20630039     DOI： 10.1111/j.1399-0039.2010.01528.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  7 in total

1.  Extensive variation at MHC DRB in the New Zealand sea lion (Phocarctos hookeri) provides evidence for balancing selection.

Authors:  A J Osborne; M Zavodna; B L Chilvers; B C Robertson; S S Negro; M A Kennedy; N J Gemmell
Journal:  Heredity (Edinb)       Date:  2013-04-10       Impact factor: 3.821

Review 2.  Major Histocompatibility Complex (MHC) markers in conservation biology.

Authors:  Beata Ujvari; Katherine Belov
Journal:  Int J Mol Sci       Date:  2011-08-15       Impact factor: 5.923

3.  High polymorphism in MHC-DRB genes in golden snub-nosed monkeys reveals balancing selection in small, isolated populations.

Authors:  Pei Zhang; Kang Huang; Bingyi Zhang; Derek W Dunn; Dan Chen; Fan Li; Xiaoguang Qi; Songtao Guo; Baoguo Li
Journal:  BMC Evol Biol       Date:  2018-03-13       Impact factor: 3.260

4.  Evolution of major histocompatibility complex class I and class II genes in the brown bear.

Authors:  Katarzyna Kuduk; Wiesław Babik; Katarzyna Bojarska; Ewa B Sliwińska; Jonas Kindberg; Pierre Taberlet; Jon E Swenson; Jacek Radwan
Journal:  BMC Evol Biol       Date:  2012-10-02       Impact factor: 3.260

5.  MHC class II DQB diversity in the Japanese black bear, Ursus thibetanus japonicus.

Authors:  Yoshiki Yasukochi; Toshifumi Kurosaki; Masaaki Yoneda; Hiroko Koike; Yoko Satta
Journal:  BMC Evol Biol       Date:  2012-11-29       Impact factor: 3.260

6.  Balancing selection and genetic drift at major histocompatibility complex class II genes in isolated populations of golden snub-nosed monkey (Rhinopithecus roxellana).

Authors:  Mao-Fang Luo; Hui-Juan Pan; Zhi-Jin Liu; Ming Li
Journal:  BMC Evol Biol       Date:  2012-10-19       Impact factor: 3.260

7.  Patterns of adaptive and neutral diversity identify the Xiaoxiangling mountains as a refuge for the giant panda.

Authors:  Yi-Yan Chen; Ying Zhu; Qiu-Hong Wan; Ji-Kang Lou; Wen-Jing Li; Yun-Fa Ge; Sheng-Guo Fang
Journal:  PLoS One       Date:  2013-07-19       Impact factor: 3.240
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.