BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) S1647T has been identified as a risk variant for Parkinson's disease (PD) in Han Chinese. METHODS: To replicate the association of LRRK2 S1647T with risk of PD, we conducted a case-control study of this variant involving 406 PD subjects and 412 controls from southern mainland China. RESULTS: The results showed that the frequency of A allele was higher in patients with PD (OR=1.238, 95% CI: 1.015-1.510, P=0.035) compared to controls. In a multivariate logistic regression analysis with the disease group (patients with PD vs. controls) as the dependent variable and genotype as an independent factor adjusting for the effect of age and gender, the homozygous S1647T genotype (AA) was associated with an increased risk of PD (OR=1.815, 95% CI:1.270-2.594, P=0.001). The pooled analysis of present data and the data from the previous work demonstrated that the frequency of A allele was higher in patients with PD (OR=1.2, 95% CI: 1.09-1.32, P<0.0001). CONCLUSIONS: LRRK2 S1647T increases the risk of Parkinson's disease in southern China.
BACKGROUND:Leucine-rich repeat kinase 2 (LRRK2) S1647T has been identified as a risk variant for Parkinson's disease (PD) in Han Chinese. METHODS: To replicate the association of LRRK2S1647T with risk of PD, we conducted a case-control study of this variant involving 406 PD subjects and 412 controls from southern mainland China. RESULTS: The results showed that the frequency of A allele was higher in patients with PD (OR=1.238, 95% CI: 1.015-1.510, P=0.035) compared to controls. In a multivariate logistic regression analysis with the disease group (patients with PD vs. controls) as the dependent variable and genotype as an independent factor adjusting for the effect of age and gender, the homozygous S1647T genotype (AA) was associated with an increased risk of PD (OR=1.815, 95% CI:1.270-2.594, P=0.001). The pooled analysis of present data and the data from the previous work demonstrated that the frequency of A allele was higher in patients with PD (OR=1.2, 95% CI: 1.09-1.32, P<0.0001). CONCLUSIONS:LRRK2S1647T increases the risk of Parkinson's disease in southern China.
Authors: Anett Illés; Dóra Csabán; Zoltán Grosz; Péter Balicza; András Gézsi; Viktor Molnár; Renáta Bencsik; Anikó Gál; Péter Klivényi; Maria Judit Molnar Journal: Front Genet Date: 2019-10-31 Impact factor: 4.599
Authors: Alexia F Kalogeropulou; Elena Purlyte; Francesca Tonelli; Sven M Lange; Melanie Wightman; Alan R Prescott; Shalini Padmanabhan; Esther Sammler; Dario R Alessi Journal: Biochem J Date: 2022-09-16 Impact factor: 3.766