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Literature DB >> 2062870

Population dynamics of natural antibodies in normal and autoimmune individuals.

F Varela¹, A Andersson, G Dietrich, A Sundblad, D Holmberg, M Kazatchkine, A Coutinho.

Abstract

We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoire, regulating the activation and decay of individual clones. The temporal changes of both disease-specific and nonspecific autoantibodies are consistently modified in autoimmune individuals.

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Year: 1991 PMID： 2062870 PMCID： PMC51989 DOI： 10.1073/pnas.88.13.5917

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Dynamics of a class of immune networks. I. Global stability of idiotype interactions.

Authors: F J Varela; J Stewart
Journal: J Theor Biol Date: 1990-05-10 Impact factor: 2.691

2. Autonomous activation of B and T cells in antigen-free mice.

Authors: P Pereira; L Forni; E L Larsson; M Cooper; C Heusser; A Coutinho
Journal: Eur J Immunol Date: 1986-06 Impact factor: 5.532

Review 3. Murine models of systemic lupus erythematosus.

Authors: A N Theofilopoulos; F J Dixon
Journal: Adv Immunol Date: 1985 Impact factor: 3.543

4. Idiotypic determinants of natural IgM antibodies that resemble self Ia antigens.

Authors: D Holmberg; S Forsgren; L Forni; F Ivars; A Coutinho
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

Review 5. Studies on natural antibodies and autoantibodies.

Authors: S Avrameas; G Dighiero; P Lymberi; B Guilbert
Journal: Ann Immunol (Paris) Date: 1983 Jul-Aug

6. Cross-reactive idiotypes of monoclonal anti-Iak antibodies: characterization with xenogeneic anti-idiotypic reagents and expression in anti-H-2 humoral responses.

Authors: C Devaux; S L Epstein; D H Sachs; M Pierres
Journal: J Immunol Date: 1982-11 Impact factor: 5.422

7. Towards a network theory of the immune system.

Authors: N K Jerne
Journal: Ann Immunol (Paris) Date: 1974-01

8. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

Authors: U D Staerz; H G Rammensee; J D Benedetto; M J Bevan
Journal: J Immunol Date: 1985-06 Impact factor: 5.422

9. Reactions among IgM antibodies derived from normal, neonatal mice.

Authors: D Holmberg; S Forsgren; F Ivars; A Coutinho
Journal: Eur J Immunol Date: 1984-05 Impact factor: 5.532

10. A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

Authors: Y Naparstek; J André-Schwartz; T Manser; L J Wysocki; L Breitman; B D Stollar; M Gefter; R S Schwartz
Journal: J Exp Med Date: 1986-08-01 Impact factor: 14.307

16 in total

1. Xenoreactive natural antibodies and induced antibodies--their effects of beating cardiomyocytes as a model of a xenograft.

Authors: U Müller-Werdan; B Koidl; A Autenrieth; D Klein; K Werdan; C Hammer
Journal: Mol Cell Biochem Date: 1996 Jul-Aug Impact factor: 3.396

10. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

Authors: R W Burlingame; R L Rubin; R S Balderas; A N Theofilopoulos
Journal: J Clin Invest Date: 1993-04 Impact factor: 14.808

Population dynamics of natural antibodies in normal and autoimmune individuals.

1. Dynamics of a class of immune networks. I. Global stability of idiotype interactions.

2. Autonomous activation of B and T cells in antigen-free mice.

Review 3. Murine models of systemic lupus erythematosus.

4. Idiotypic determinants of natural IgM antibodies that resemble self Ia antigens.

Review 5. Studies on natural antibodies and autoantibodies.

6. Cross-reactive idiotypes of monoclonal anti-Iak antibodies: characterization with xenogeneic anti-idiotypic reagents and expression in anti-H-2 humoral responses.

7. Towards a network theory of the immune system.

8. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

9. Reactions among IgM antibodies derived from normal, neonatal mice.

10. A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

1. Xenoreactive natural antibodies and induced antibodies--their effects of beating cardiomyocytes as a model of a xenograft.

2. A Cayley tree immune network model with antibody dynamics.

3. Complex behaviours of AB model describing idiotypic network.

4. Immune network behavior--II. From oscillations to chaos and stationary states.

5. Immune network behavior--I. From stationary states to limit cycle oscillations.

Review 6. Treatment of autoimmune diseases with normal immunoglobulin through manipulation of the idiotypic network.

Review 7. Treatment of autoimmune diseases and systemic vasculitis with pooled human intravenous immune globulin.

Review 8. Immunomodulating effects of intravenous immunoglobulin in autoimmune and inflammatory diseases.

9. The natural antibody repertoire of sharks and humans recognizes the potential universe of antigens.

10. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.