Literature DB >> 20628445

Can autism be triggered by acetaminophen activation of the endocannabinoid system?

Stephen T Schultz1.   

Abstract

Acetaminophen use in children has been associated with increased autism risk. Recent evidence suggests that acetaminophen's analgesic actions result from activation of the endocannabinoid system, and activation of this system can have neuromodulatory consequences during development. This investigation was performed to determine if there is evidence to support the hypothesis that acetaminophen use can trigger autism by activation of the endocannabinoid system.

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Year:  2010        PMID： 20628445

Source DB:  PubMed          Journal:  Acta Neurobiol Exp (Wars)        ISSN： 0065-1400            Impact factor:   1.579


  13 in total

Review 1.  Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003-2013.

Authors:  M Ng; J G de Montigny; M Ofner; M T Do
Journal:  Health Promot Chronic Dis Prev Can       Date:  2017-01       Impact factor: 3.240

2.  Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats.

Authors:  Abdulaziz S Saeedan; Indu Singh; Mohd Nazam Ansari; Manjari Singh; Jitendra K Rawat; Uma Devi; Swetlana Gautam; Rajnish K Yadav; Gaurav Kaithwas
Journal:  Inflammopharmacology       Date:  2018-01-11       Impact factor: 4.473

3.  Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice.

Authors:  Georgianna G Gould; Alexandre Seillier; Gabriela Weiss; Andrea Giuffrida; Teresa F Burke; Julie G Hensler; Crystal Rock; Amanda Tristan; Lance R McMahon; Alexander Salazar; Jason C O'Connor; Neera Satsangi; Rajiv K Satsangi; Ting-Ting Gu; Keenan Treat; Corey Smolik; Stephen T Schultz
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2012-04-21       Impact factor: 5.067

4.  Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.

Authors:  Dario Siniscalco; Anna Sapone; Catia Giordano; Alessandra Cirillo; Laura de Magistris; Francesco Rossi; Alessio Fasano; James Jeffrey Bradstreet; Sabatino Maione; Nicola Antonucci
Journal:  J Autism Dev Disord       Date:  2013-11

5.  Prenatal and perinatal analgesic exposure and autism: an ecological link.

Authors:  Ann Z Bauer; David Kriebel
Journal:  Environ Health       Date:  2013-05-09       Impact factor: 5.984

6.  A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic?

Authors:  Staci D Bilbo; Cynthia D Nevison; William Parker
Journal:  Microb Ecol Health Dis       Date:  2015-01-28

7.  Organic Compounds Detected in Deciduous Teeth: A Replication Study from Children with Autism in Two Samples.

Authors:  Raymond F Palmer; Lynne Heilbrun; David Camann; Alice Yau; Stephen Schultz; Viola Elisco; Beatriz Tapia; Noe Garza; Claudia Miller
Journal:  J Environ Public Health       Date:  2015-07-29

Review 8.  Endocannabinoid Signaling in Autism.

Authors:  Bhismadev Chakrabarti; Antonio Persico; Natalia Battista; Mauro Maccarrone
Journal:  Neurotherapeutics       Date:  2015-10       Impact factor: 7.620

Review 9.  The dynamics of autism spectrum disorders: how neurotoxic compounds and neurotransmitters interact.

Authors:  Ilona Quaak; Madeleine R Brouns; Margot Van de Bor
Journal:  Int J Environ Res Public Health       Date:  2013-08-06       Impact factor: 3.390

10.  Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder.

Authors:  Stephen T Schultz; Georgianna G Gould
Journal:  Autism Open Access       Date:  2016-03-28
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