Literature DB >> 2062782

Disseminated gonococcal infection associated with deficiency of the second component of complement.

P H McWhinney1, P Langhorne, W C Love, K Whaley.   

Abstract

A case of C2 deficiency presenting with disseminated gonococcal infection is described. The predisposition of C2-deficient individuals to infection in addition to the commoner problem of immune complex diseases is noted. Attention is drawn to the absence of documented cases of gonococcal infection associated with C2 deficiency. No other homozygous C2 deficient family members were identified. Lifelong penicillin prophylaxis was recommended for the patient.

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Year:  1991        PMID： 2062782      PMCID： PMC2399001          DOI： 10.1136/pgmj.67.785.297

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  5 in total

1.  Complement, the immune-complex lattice, and the pathophysiology of complement-deficiency syndromes.

Authors:  J A Schifferli; D K Peters
Journal:  Lancet       Date:  1983-10-22       Impact factor: 79.321

2.  New microbial and host factors in disseminated gonococcal infection: case report.

Authors:  G E Forster; A J Pinching; C A Ison; C S Easmon; P E Munday
Journal:  Genitourin Med       Date:  1987-06

3.  Neisseria meningitidis and Neisseria gonorrhoeae bacteremia associated with C6, C7, or C8 deficiency.

Authors:  B H Petersen; T J Lee; R Snyderman; G F Brooks
Journal:  Ann Intern Med       Date:  1979-06       Impact factor: 25.391

Review 4.  Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.

Authors:  S C Ross; P Densen
Journal:  Medicine (Baltimore)       Date:  1984-09       Impact factor: 1.889

5.  Underlying complement deficiency in patients with disseminated gonococcal infection.

Authors:  R T Ellison; J G Curd; P F Kohler; L B Reller; F N Judson
Journal:  Sex Transm Dis       Date:  1987 Oct-Dec       Impact factor: 2.830
  5 in total
  6 in total

1.  Disseminated gonococcal infection in an elderly patient.

Authors:  I Rúa Figueroa; E Loza Cortina; S González Suárez; C E Arruabarrena; J L Peña Sagredo
Journal:  Ann Rheum Dis       Date:  1993-01       Impact factor: 19.103

Review 2.  Infections of people with complement deficiencies and patients who have undergone splenectomy.

Authors:  Sanjay Ram; Lisa A Lewis; Peter A Rice
Journal:  Clin Microbiol Rev       Date:  2010-10       Impact factor: 26.132

3.  Phylogenomic Comparison of Neisseria gonorrhoeae Causing Disseminated Gonococcal Infections and Uncomplicated Gonorrhea in Georgia, United States.

Authors:  John C Cartee; Sandeep J Joseph; Emily Weston; Cau D Pham; Jesse C Thomas; Karen Schlanger; Sancta B St Cyr; Monica M Farley; Ashley E Moore; Amy K Tunali; Charletta Cloud; Brian H Raphael
Journal:  Open Forum Infect Dis       Date:  2022-05-13       Impact factor: 4.423

4.  Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Authors:  Sunita Gulati; Frank J Beurskens; Bart-Jan de Kreuk; Marcel Roza; Bo Zheng; Rosane B DeOliveira; Jutamas Shaughnessy; Nancy A Nowak; Ronald P Taylor; Marina Botto; Xianbao He; Robin R Ingalls; Trent M Woodruff; Wen-Chao Song; Janine Schuurman; Peter A Rice; Sanjay Ram
Journal:  PLoS Biol       Date:  2019-06-19       Impact factor: 8.029

5.  An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae.

Authors:  Jutamas Shaughnessy; Aleyo Chabeda; Y Tran; Bo Zheng; Nancy Nowak; Carolynn Steffens; Rosane B DeOliveira; Sunita Gulati; Lisa A Lewis; James Maclean; John A Moss; Keith L Wycoff; Sanjay Ram
Journal:  Front Immunol       Date:  2022-08-30       Impact factor: 8.786

6.  Development of Complement Factor H-Based Immunotherapeutic Molecules in Tobacco Plants Against Multidrug-Resistant Neisseria gonorrhoeae.

Authors:  Jutamas Shaughnessy; Y Tran; Bo Zheng; Rosane B DeOliveira; Sunita Gulati; Wen-Chao Song; James M Maclean; Keith L Wycoff; Sanjay Ram
Journal:  Front Immunol       Date:  2020-10-26       Impact factor: 7.561
  6 in total

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