Literature DB >> 20627724

Synthesis and biological evaluation of indolyl chalcones as antitumor agents.

Dalip Kumar1, N Maruthi Kumar, Kanako Akamatsu, Eriko Kusaka, Hiroshi Harada, Takeo Ito.   

Abstract

A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20627724     DOI： 10.1016/j.bmcl.2010.05.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

1.  Solvent effect profiles of absorbance and fluorescence spectra of some indole based chalcones.

Authors:  Manju Kumari Saroj; Neera Sharma; Ramesh C Rastogi
Journal:  J Fluoresc       Date:  2011-08-09       Impact factor: 2.217

2.  6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability.

Authors:  Shengnan Du; Jeffrey G Sarver; Christopher J Trabbic; Paul W Erhardt; Allen Schroering; William A Maltese
Journal:  Cancer Chemother Pharmacol       Date:  2018-11-13       Impact factor: 3.333

3.  Novel indolyl-chalcones target stathmin to induce cancer cell death.

Authors:  Barbara Wegiel; Yiqiang Wang; Mailin Li; Finith Jernigan; Lijun Sun
Journal:  Cell Cycle       Date:  2016-03-17       Impact factor: 4.534

4.  Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.

Authors:  Yiqiang Wang; Andreas Hedblom; Steffi K Koerner; Mailin Li; Finith E Jernigan; Barbara Wegiel; Lijun Sun
Journal:  Bioorg Med Chem Lett       Date:  2016-10-24       Impact factor: 2.823

5.  Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death.

Authors:  Michael W Robinson; Jean H Overmeyer; Ashley M Young; Paul W Erhardt; William A Maltese
Journal:  J Med Chem       Date:  2012-02-28       Impact factor: 7.446

6.  Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

Authors:  Sultan Nacak Baytas; Nazan Inceler; Akin Yilmaz; Abdurrahman Olgac; Sevda Menevse; Erden Banoglu; Ernest Hamel; Roberta Bortolozzi; Giampietro Viola
Journal:  Bioorg Med Chem       Date:  2014-04-20       Impact factor: 3.641

7.  Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: Effects on potency and mode of activity.

Authors:  Christopher J Trabbic; Sage M George; Evan M Alexander; Shengnan Du; Jennifer M Offenbacher; Emily J Crissman; Jean H Overmeyer; William A Maltese; Paul W Erhardt
Journal:  Eur J Med Chem       Date:  2016-06-13       Impact factor: 6.514

8.  Straightforward synthesis of thiazoline-incorporated chalconoids from phenacyl halides.

Authors:  Adile Ayati; Saeed Emami
Journal:  Mol Divers       Date:  2013-01-12       Impact factor: 2.943

9.  A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells.

Authors:  Jean H Overmeyer; Ashley M Young; Haymanti Bhanot; William A Maltese
Journal:  Mol Cancer       Date:  2011-06-06       Impact factor: 27.401

10.  Synthesis and in vitro inhibition effect of new pyrido[2,3-d]pyrimidine derivatives on erythrocyte carbonic anhydrase I and II.

Authors:  Hilal Kuday; Fatih Sonmez; Cigdem Bilen; Emre Yavuz; Nahit Gençer; Mustafa Kucukislamoglu
Journal:  Biomed Res Int       Date:  2014-08-04       Impact factor: 3.411
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