Literature DB >> 20627559

Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.

Heidi R Bokesch1, Laura K Cartner, Richard W Fuller, Jennifer A Wilson, Curtis J Henrich, James A Kelley, Kirk R Gustafson, James B McMahon, Tawnya C McKee.   

Abstract

Five new naphthopyrones (1-5) along with the known compounds TMC-256A1, 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one, TMC-256C1, comaparvin, 6-methoxycomaparvin, and 6-methoxycomaparvin 5-methyl ether (6-11) were isolated from crinoids of the family Comasteridae. All compounds were tested for their ability to inhibit the multidrug transporter ABCG2, which plays a role in drug resistance. Six of the seven angular naphthopyrones showed moderate activity with <60% inhibition of ABCG2-mediated transport as compared to the positive control fumitremorgin C. None of the linear naphthopyrones inhibited ABCG2-mediated efflux. Published by Elsevier Ltd.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20627559      PMCID： PMC2924950          DOI： 10.1016/j.bmcl.2010.05.057

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus.

Authors:  Florence Folmer; William T A Harrison; Jioji N Tabudravu; Marcel Jaspars; William Aalbersberg; Klaus Feussner; Anthony D Wright; Mario Dicato; Marc Diederich
Journal:  J Nat Prod       Date:  2007-12-19       Impact factor: 4.050

2.  Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

Authors:  M Maliepaard; G L Scheffer; I F Faneyte; M A van Gastelen; A C Pijnenborg; A H Schinkel; M J van De Vijver; R J Scheper; J H Schellens
Journal:  Cancer Res       Date:  2001-04-15       Impact factor: 12.701

3.  TMC-256A1 and C1, new inhibitors of IL-4 signal transduction produced by Aspergillus niger var niger TC 1629.

Authors:  Masaaki Sakurai; Jun Kohno; Kouzou Yamamoto; Toru Okuda; Maki Nishio; Kimio Kawano; Tetsuo Ohnuki
Journal:  J Antibiot (Tokyo)       Date:  2002-08       Impact factor: 2.649

4.  Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

Authors:  J W Jonker; J W Smit; R F Brinkhuis; M Maliepaard; J H Beijnen; J H Schellens; A H Schinkel
Journal:  J Natl Cancer Inst       Date:  2000-10-18       Impact factor: 13.506

5.  A high-throughput cell-based assay for inhibitors of ABCG2 activity.

Authors:  Curtis J Henrich; Heidi R Bokesch; Michael Dean; Susan E Bates; Robert W Robey; Ekaterina I Goncharova; Jennifer A Wilson; James B McMahon
Journal:  J Biomol Screen       Date:  2006-02-20

6.  Botryllamides: natural product inhibitors of ABCG2.

Authors:  Curtis J Henrich; Robert W Robey; Kentaro Takada; Heidi R Bokesch; Susan E Bates; Suneet Shukla; Suresh V Ambudkar; James B McMahon; Kirk R Gustafson
Journal:  ACS Chem Biol       Date:  2009-08-21       Impact factor: 5.100

7.  Aspergillus species strain M39 produces two naphtho-gamma-pyrones that reverse drug resistance in human KB cells.

Authors:  S Ikeda; M Sugita; A Yoshimura; T Sumizawa; H Douzono; Y Nagata; S Akiyama
Journal:  Int J Cancer       Date:  1990-03-15       Impact factor: 7.396
  7 in total
  2 in total

1.  New Antioxidant Active Packaging Films Based on Yeast Cell Wall and Naphtho-γ-Pyrone Extract.

Authors:  Guillermo D Rezzani; Elodie Choque; Andrés G Salvay; Florence Mathieu; Mercedes A Peltzer
Journal:  Polymers (Basel)       Date:  2022-05-18       Impact factor: 4.967

Review 2.  Marine natural products as breast cancer resistance protein inhibitors.

Authors:  Lilia Cherigo; Dioxelis Lopez; Sergio Martinez-Luis
Journal:  Mar Drugs       Date:  2015-04-03       Impact factor: 5.118
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.