Literature DB >> 206273

Enhancing and inhibiting effects of spleen cells from tumour-bearing mice on growth of virus-induced primary sarcoma.

H Kimura, T Aoki.   

Abstract

The effects of adoptive transfer of spleen cells from tumour-bearing mice on the growth of Moloney murine sarcoma virus (M-MuSV)-induced primary tumours in BALB/c mice were studied. The effects were in 2 directions, depending on the time of lymphocyte inoculation; when spleen cells from tumuor-bearing mice 12 days after M-MuSV inoculation were inoculated into recipient mice before M-MuSV inoculation, the appearance of tumours was significantly delayed and their incidence was reduced, whereas when these lymphocytes were inoculated after the development of tumours in recipient mice, tumour growth was significantly enhanced. The data indicated that these inhibiting and enhancing effects were mediated mainly by T cells. The mechanisms of the parodoxical effects were investigated.

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Year:  1978        PMID： 206273      PMCID： PMC2009566          DOI： 10.1038/bjc.1978.84

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  30 in total

1.  Cellular and humoral immunity after allogeneic renal transplantation in the rat. V. Appearance of anti-idiotypic antibody and its relationship to cellular immunity after treatment with donor spleen cells and alloantibody.

Authors:  F P Stuart; D M Scollard; T J McKearn; F W Fitch
Journal:  Transplantation       Date:  1976-11       Impact factor: 4.939

2.  Kinetics of the response of spleen cells from tumor-bearing animals in an in vivo tumor neutralization assay.

Authors:  A Gabizon; M Small; N Trainin
Journal:  Int J Cancer       Date:  1976-12-15       Impact factor: 7.396

3.  Specificity of 51Cr-release cytotoxicity of lymphocytes immune to murine sarcoma virus.

Authors:  R B Herberman; T Aoki; M Nunn; D H Lavrin; N Soares; A Gazdar; H Holden; K S Chang
Journal:  J Natl Cancer Inst       Date:  1974-10       Impact factor: 13.506

4.  In vitro cytotoxicity and in vivo tumor enhancement induced by mouse spleen cells autosensitized in vitro.

Authors:  D Ilfeld; C Carnaud; I R Cohen; N Trainin
Journal:  Int J Cancer       Date:  1973-07-15       Impact factor: 7.396

5.  The lymphocyte response to a primary viral neoplasm (MSV) through its entire course in BALB-c mice.

Authors:  E W Lamon; H M Skurzak; E Klein
Journal:  Int J Cancer       Date:  1972-11       Impact factor: 7.396

6.  Colony inhibition studies on blocking and non-blocking serum effects on cellular immunity to Moloney sarcomas.

Authors:  I Hellström; K E Hellström
Journal:  Int J Cancer       Date:  1970-03-15       Impact factor: 7.396

7.  Synergism between immune complexes and serum from tumor-bearing mice in the suppression of mitogen responses.

Authors:  D G Kilburn; M Fairhurst; J G Levy; R B Whitney
Journal:  J Immunol       Date:  1976-11       Impact factor: 5.422

8.  Immunosuppression of T lymphocyte function by fractionated serum from tumor-bearing mice.

Authors:  R McMaster; K Buhler; R Whitney; J G Levy
Journal:  J Immunol       Date:  1977-01       Impact factor: 5.422

9.  Cell-mediated reaction against tumors induced by oncornaviruses. I. Kinetics and specificity of the immune response in murine sarcoma virus (MSV)-induced tumors and transplanted lymphomas.

Authors:  J C Leclerc; E Gomard; J P Levy
Journal:  Int J Cancer       Date:  1972-11       Impact factor: 7.396

10.  Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.

Authors:  K Kawashima; H Ikeda; J W Hartley; E Stockert; W P Rowe; L J Old
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205
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  1 in total

1.  Effect of recombinant human interleukin 2 on the growth of a BALB/c sarcoma induced by Moloney murine sarcoma virus.

Authors:  S Mitsunaga; H Kimura; Y Yamaguchi; A Mikata
Journal:  Jpn J Cancer Res       Date:  1988-08
  1 in total

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