Literature DB >> 20627186

Clinical instability as a predictor of negative outcomes among elderly patients admitted to a rehabilitation ward.

Fabio Guerini1, Giovanni B Frisoni, Sara Morghen, Salvatore Speciale, Giuseppe Bellelli, Marco Trabucchi.   

Abstract

OBJECTIVES: To assess the impact of clinical instability (CI) and delirium on admission to a rehabilitation unit on clinical and functional outcomes (death, transfer to acute care, poor functional recovery) at discharge, in a population of elderly patients.
DESIGN: Observational study.
SETTING: Rehabilitation and Aged Care Unit (RACU). PARTICIPANTS: Participants were 583 consecutively and firstly admitted elderly patients. MEASUREMENTS: On admission, all patients underwent a comprehensive geriatric assessment including sociodemographics, cognitive and depressive symptoms, nutritional status, physical health, and functional status. CI was recorded for all patients on admission, assessing 5 vital signs (temperature, heart rate, systolic blood pressure, respiratory rate, and oxygen saturation). Delirium was assessed daily with the Confusion Assessment Method.
RESULTS: Patients were on average old (mean age: 77.8 +/- 9.8), predominantly female (68.6%), with mild cognitive deterioration (MMSE: 22.1 +/- 6.3) and depressive symptoms (GDS: 5.9 +/- 3.5). They had moderate comorbidity (means CIRS: 3.1 +/- 1.9), and functional impairment both before (Barthel Index pre-admission: 84.5 +/- 19.2; IADL: 3.3 +/- 3.0) and on admission (Barthel Index: 55.8 +/- 27.5). On admission, 136 (23.3%) patients were classified as clinically unstable: 76 (13%) had either CI or delirium, and 60 (10.3%) had CI associated to delirium. At discharge, 26 patients were transferred to acute care hospitals, and 14 died. Transfer to acute care occurred in more than 10% of patients with almost one altered condition (CI or delirium), and in one fifth of patients with the association of CI and delirium. In-RACU death was observed only in this latter group. Functional recovery at discharge was significantly higher in stable patients than in patients with CI and/or delirium.
CONCLUSIONS: CI and delirium are useful prognostic markers of adverse clinical and functional outcomes in a population of elderly subjects admitted to a rehabilitative unit. 2010 American Medical Directors Association. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20627186     DOI: 10.1016/j.jamda.2009.10.005

Source DB:  PubMed          Journal:  J Am Med Dir Assoc        ISSN: 1525-8610            Impact factor:   4.669


  7 in total

1.  Inpatient Rehabilitation Delirium Screening: Impact on Acute Care Transfers and Functional Outcomes.

Authors:  Sharon Bushi; A M Barrett; Mooyeon Oh-Park
Journal:  PM R       Date:  2020-01-16       Impact factor: 2.298

2.  EPO-cyclosporine combination therapy reduced brain infarct area in rat after acute ischemic stroke: role of innate immune-inflammatory response, micro-RNAs and MAPK family signaling pathway.

Authors:  Chun-Man Yuen; Kuo-Ho Yeh; Christopher Glenn Wallace; Kuan-Hung Chen; Hung-Sheng Lin; Pei-Hsun Sung; Han-Tan Chai; Yung-Lung Chen; Cheuk-Kwan Sun; Chih-Hung Chen; Gour-Shenq Kao; Sheung-Fat Ko; Hon-Kan Yip
Journal:  Am J Transl Res       Date:  2017-04-15       Impact factor: 4.060

3.  Predictors of rehospitalization among elderly patients admitted to a rehabilitation hospital: the role of polypharmacy, functional status, and length of stay.

Authors:  Alessandro Morandi; Giuseppe Bellelli; Eduard E Vasilevskis; Renato Turco; Fabio Guerini; Tiziana Torpilliesi; Salvatore Speciale; Valeria Emiliani; Simona Gentile; John Schnelle; Marco Trabucchi
Journal:  J Am Med Dir Assoc       Date:  2013-05-07       Impact factor: 4.669

4.  Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial.

Authors:  Tzu-Hsien Tsai; Cheng-Hsien Lu; Christopher Glenn Wallace; Wen-Neng Chang; Shu-Feng Chen; Chi-Ren Huang; Nai-Wen Tsai; Min-Yu Lan; Pei-Hsun Sung; Chu-Feng Liu; Hon-Kan Yip
Journal:  Crit Care       Date:  2015-02-25       Impact factor: 9.097

Review 5.  Is Delirium the Cognitive Harbinger of Frailty in Older Adults? A Review about the Existing Evidence.

Authors:  Giuseppe Bellelli; Rosamaria Moresco; Paola Panina-Bordignon; Beatrice Arosio; Cecilia Gelfi; Alessandro Morandi; Matteo Cesari
Journal:  Front Med (Lausanne)       Date:  2017-11-08

6.  Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke.

Authors:  Hee Won Yang; Miji Lee; Jong Wook Shin; Hye Seon Jeong; Jei Kim; Jeong Lan Kim
Journal:  Psychiatry Investig       Date:  2019-10-28       Impact factor: 2.505

7.  Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: results of a prospective multi-centre study on World Delirium Awareness Day.

Authors: 
Journal:  BMC Med       Date:  2019-12-14       Impact factor: 8.775

  7 in total

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