INTRODUCTION: Insomnia symptoms, which are common in depression, have a significant impact on function and quality of life. However, little is known about the prevalence and associated features of insomnia symptoms in representative treatment-seeking patients with depression. METHODS: Data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were analyzed. STAR*D recruited 3,743 adult outpatients diagnosed with nonpsychotic major depressive disorder (MDD) from primary (n=18) and psychiatric care (n=23) clinics across the United States. Baseline sociodemographic and clinical features were compared between those with insomnia symptoms (84.7%) and those without (15.3%). RESULTS: The most common presentation was the simultaneous presence of sleep onset, mid-nocturnal, and early morning insomnia symptoms (27.1%). Of these three types of insomnia symptoms, mid-nocturnal insomnia symptoms were the most commonly found alone (13.5%) and in combination with one or more other types (82.3%). Insomnia symptoms were associated with several indicators of a more severe depressive illness. Only a small proportion of participants with insomnia symptoms were receiving treatment for sleep disturbances at study initiation, and the vast majority of those receiving treatment still reported having insomnia symptoms. CONCLUSION: In outpatients who seek treatment for nonpsychotic MDD in typical clinical settings, insomnia symptoms are very common, undertreated, and indicative of a more severe depression.
INTRODUCTION:Insomnia symptoms, which are common in depression, have a significant impact on function and quality of life. However, little is known about the prevalence and associated features of insomnia symptoms in representative treatment-seeking patients with depression. METHODS: Data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were analyzed. STAR*D recruited 3,743 adult outpatients diagnosed with nonpsychotic major depressive disorder (MDD) from primary (n=18) and psychiatric care (n=23) clinics across the United States. Baseline sociodemographic and clinical features were compared between those with insomnia symptoms (84.7%) and those without (15.3%). RESULTS: The most common presentation was the simultaneous presence of sleep onset, mid-nocturnal, and early morning insomnia symptoms (27.1%). Of these three types of insomnia symptoms, mid-nocturnal insomnia symptoms were the most commonly found alone (13.5%) and in combination with one or more other types (82.3%). Insomnia symptoms were associated with several indicators of a more severe depressive illness. Only a small proportion of participants with insomnia symptoms were receiving treatment for sleep disturbances at study initiation, and the vast majority of those receiving treatment still reported having insomnia symptoms. CONCLUSION: In outpatients who seek treatment for nonpsychotic MDD in typical clinical settings, insomnia symptoms are very common, undertreated, and indicative of a more severe depression.
Authors: Diana A Chirinos; Indira Gurubhagavatula; Preston Broderick; Julio A Chirinos; Karen Teff; Thomas Wadden; Greg Maislin; Hassam Saif; Jesse Chittams; Caitlin Cassidy; Alexandra L Hanlon; Allan I Pack Journal: J Behav Med Date: 2017-06-21
Authors: A Irem Sonmez; M Utku Kucuker; Charles P Lewis; Bhanu Prakash Kolla; Deniz Doruk Camsari; Jennifer L Vande Voort; Kathryn M Schak; Simon Kung; Paul E Croarkin Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2019-10-18 Impact factor: 5.067
Authors: Emerson M Wickwire; Sarah E Tom; Steven M Scharf; Aparna Vadlamani; Ilynn G Bulatao; Jennifer S Albrecht Journal: Sleep Date: 2019-04-01 Impact factor: 5.849
Authors: Leslie M Swanson; Edward D Huntley; Holli Bertram; Ann Mooney; Richard Dopp; Robert Hoffmann; Roseanne Armitage; J Todd Arnedt Journal: Behav Sleep Med Date: 2016-08-05 Impact factor: 2.964