PURPOSE: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. METHODS:Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. RESULTS: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. CONCLUSION: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.
RCT Entities:
PURPOSE: A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. METHODS: Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. RESULTS: Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. CONCLUSION: A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.
Authors: M H Antoni; J M Lehman; K M Kilbourn; A E Boyers; J L Culver; S M Alferi; S E Yount; B A McGregor; P L Arena; S D Harris; A A Price; C S Carver Journal: Health Psychol Date: 2001-01 Impact factor: 4.267
Authors: Paul B Jacobsen; Ian J Sadler; Margaret Booth-Jones; Elizabeth Soety; Michael A Weitzner; Karen K Fields Journal: J Consult Clin Psychol Date: 2002-02
Authors: C E Mosher; K N DuHamel; C M Rini; Y Li; L Isola; L Labay; S Rowley; E Papadopoulos; C Moskowitz; E Scigliano; C Grosskreutz; W H Redd Journal: Bone Marrow Transplant Date: 2009-07-13 Impact factor: 5.483
Authors: Katherine N DuHamel; Jamie Ostrof; Teresa Ashman; Gary Winkel; Elizabeth A Mundy; Terence M Keane; Benjamin J Morasco; Suzanne M J Vickberg; Karen Hurley; Jack Burkhalter; Rosy Chhabra; Eileen Scigliano; Esperanza Papadopoulos; Craig Moskowitz; William Redd Journal: Psychol Assess Date: 2004-09
Authors: Christopher M Callahan; Frederick W Unverzagt; Siu L Hui; Anthony J Perkins; Hugh C Hendrie Journal: Med Care Date: 2002-09 Impact factor: 2.983
Authors: Karen L Syrjala; Jean C Yi; Samantha B Artherholt; Joan M Romano; Marie-Laure Crouch; Allison S Fiscalini; Mark T Hegel; Mary E D Flowers; Paul J Martin; Wendy M Leisenring Journal: J Cancer Surviv Date: 2018-05-05 Impact factor: 4.442
Authors: Anna Barata; Brian D Gonzalez; Steven K Sutton; Brent J Small; Paul B Jacobsen; Teresa Field; Hugo Fernandez; Heather Sl Jim Journal: J Health Psychol Date: 2016-04-22
Authors: Lisa M Wu; Jane Austin; Jada G Hamilton; Heiddis Valdimarsdottir; Luis Isola; Scott Rowley; Rachel Warbet; Gary Winkel; William H Redd; Christine Rini Journal: Psychooncology Date: 2011-07-08 Impact factor: 3.894
Authors: Margaret Bevans; Areej El-Jawahri; D Kathryn Tierney; Lori Wiener; William A Wood; Flora Hoodin; Erin E Kent; Paul B Jacobsen; Stephanie J Lee; Matthew M Hsieh; Ellen M Denzen; Karen L Syrjala Journal: Biol Blood Marrow Transplant Date: 2016-09-19 Impact factor: 5.742
Authors: Karen Clark; Paul Greene; Kate DuHamel; Matthew Loscalzo; Marcia Grant; Kim Glazier; William Redd Journal: J Cancer Educ Date: 2012-12 Impact factor: 2.037