Literature DB >> 20624441

Mitochondrial dysfunction and Alzheimer's disease.

Aleksandra Maruszak1, Cezary Żekanowski.   

Abstract

To date, one of the most discussed hypotheses for Alzheimer's disease (AD) etiology implicates mitochondrial dysfunction and oxidative stress as one of the primary events in the course of AD. In this review we focus on the role of mitochondria and mitochondrial DNA (mtDNA) variation in AD and discuss the rationale for the involvement of mitochondrial abnormalities in AD pathology. We summarize the current data regarding the proteins involved in mitochondrial function and pathology observed in AD, and discuss the role of somatic mutations and mitochondrial haplogroups in AD development.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20624441     DOI： 10.1016/j.pnpbp.2010.07.004

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN： 0278-5846            Impact factor:   5.067


  35 in total

1.  A novel bi-level meta-analysis approach: applied to biological pathway analysis.

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Journal:  Bioinformatics       Date:  2015-10-14       Impact factor: 6.937

2.  Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function.

Authors:  Diego Mastroeni; Omar M Khdour; Pablo M Arce; Sidney M Hecht; Paul D Coleman
Journal:  ACS Chem Neurosci       Date:  2015-02-24       Impact factor: 4.418

Review 3.  Estrogen: a master regulator of bioenergetic systems in the brain and body.

Authors:  Jamaica R Rettberg; Jia Yao; Roberta Diaz Brinton
Journal:  Front Neuroendocrinol       Date:  2013-08-29       Impact factor: 8.606

4.  DANUBE: Data-driven meta-ANalysis using UnBiased Empirical distributions-applied to biological pathway analysis.

Authors:  Tin Nguyen; Cristina Mitrea; Rebecca Tagett; Sorin Draghici
Journal:  Proc IEEE Inst Electr Electron Eng       Date:  2016-03-31       Impact factor: 10.961

Review 5.  Exercise as a Positive Modulator of Brain Function.

Authors:  Karim A Alkadhi
Journal:  Mol Neurobiol       Date:  2017-05-02       Impact factor: 5.590

6.  Cataract may be a non-memory feature of Alzheimer's disease in older people.

Authors:  Shih-Wei Lai; Cheng-Li Lin; Kuan-Fu Liao
Journal:  Eur J Epidemiol       Date:  2014-04-22       Impact factor: 8.082

Review 7.  A possible role for mitochondrial dysfunction in migraine.

Authors:  S Stuart; L R Griffiths
Journal:  Mol Genet Genomics       Date:  2012-10-07       Impact factor: 3.291

8.  Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease.

Authors:  Pollyana Feldhaus; Daiane B Fraga; Fernando V Ghedim; Renata D De Luca; Thiago D Bruna; Matheus Heluany; Maria Paula Matos; Gabriela K Ferreira; Isabela C Jeremias; Claudia Heluany; Emilio L Streck; Alexandra I Zugno
Journal:  Metab Brain Dis       Date:  2011-07-26       Impact factor: 3.584

Review 9.  Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease.

Authors:  Pradip K Kamat; Anuradha Kalani; Philip Kyles; Suresh C Tyagi; Neetu Tyagi
Journal:  Cell Biochem Biophys       Date:  2014-11       Impact factor: 2.194

10.  Cortical metabolic deficits in a rat model of cholinergic basal forebrain degeneration.

Authors:  Francesca Gelfo; Laura Petrosini; Alessandro Graziano; Paola De Bartolo; Lorena Burello; Emilia Vitale; Arianna Polverino; Antonietta Iuliano; Giuseppe Sorrentino; Laura Mandolesi
Journal:  Neurochem Res       Date:  2013-08-08       Impact factor: 3.996
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