Literature DB >> 20624055

Bioastronautics: the influence of microgravity on astronaut health.

Elizabeth Blaber1, Helder Marçal, Brendan P Burns.   

Abstract

For thousands of years different cultures around the world have assigned their own meaning to the Universe. Through research and technology, we have begun to understand the nature and mysteries of the Cosmos. Last year marked the 40(th) anniversary of our first steps on the Moon, and within two decades it is hoped that humankind will have established a settlement on Mars. Space is a harsh environment, and technological advancements in material science, robotics, power generation, and medical equipment will be required to ensure that astronauts survive interplanetary journeys and settlements. The innovative field of bioastronautics aims to address some of the medical issues astronauts encounter during space travel. Astronauts are faced with several health risks during both short- and long-duration spaceflight due to the hostile environment presented in space. Some of these health problems include bone loss, muscle atrophy, cardiac dysrhythmias, and altered orientation. This review discusses the effects of spaceflight on living organisms, in particular, the specific effects of microgravity on the human body and possible countermeasures to these effects.

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Year:  2010        PMID: 20624055     DOI: 10.1089/ast.2009.0415

Source DB:  PubMed          Journal:  Astrobiology        ISSN: 1557-8070            Impact factor:   4.335


  28 in total

1.  Effects of simulated microgravity by RCCS on the biological features of Candida albicans.

Authors:  Wenjun Jiang; Bingxin Xu; Yong Yi; Yuling Huang; Xiao-Ou Li; Fuquan Jiang; Jinlian Zhou; Jianzhong Zhang; Yan Cui
Journal:  Int J Clin Exp Pathol       Date:  2014-06-15

2.  Effects of Hindlimb Unweighting on MBP and GDNF Expression and Morphology in Rat Dorsal Root Ganglia Neurons.

Authors:  Heng Zhang; Ning-Tao Ren; Fang-Qiang Zhou; Jie Li; Wei Lei; Ning Liu; Long Bi; Zi-Xiang Wu; Ran Zhang; Yong-Gang Zhang; Geng Cui
Journal:  Neurochem Res       Date:  2016-05-26       Impact factor: 3.996

3.  A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading.

Authors:  M C Walb; P J Black; V S Payne; M T Munley; J S Willey
Journal:  Life Sci Space Res (Amst)       Date:  2015-07

4.  Microgravity activates p38 MAPK-C/EBPβ pathway to regulate the expression of arginase and inflammatory cytokines in macrophages.

Authors:  Chongzhen Wang; Hui Chen; Haiying Luo; Linnan Zhu; Yang Zhao; Hongling Tian; Ruoyu Wang; Peng Shang; Yong Zhao
Journal:  Inflamm Res       Date:  2015-03-25       Impact factor: 4.575

5.  3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome.

Authors:  Mei ElGindi; Jiranuwat Sapudom; Praveen Laws; Anna Garcia-Sabaté; Mohammed F Daqaq; Jeremy Teo
Journal:  Cell Mol Life Sci       Date:  2022-09-05       Impact factor: 9.207

6.  Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-α expression in macrophage cells.

Authors:  Chongzhen Wang; Haiying Luo; Linnan Zhu; Fan Yang; Zhulang Chu; Hongling Tian; Meifu Feng; Yong Zhao; Peng Shang
Journal:  Inflamm Res       Date:  2013-11-06       Impact factor: 4.575

7.  Simulated microgravity affects chondrogenesis and hypertrophy of human mesenchymal stem cells.

Authors:  Susanne Mayer-Wagner; Florian Hammerschmid; Julia I Redeker; Bärbel Schmitt; Boris Michael Holzapfel; Volkmar Jansson; Oliver B Betz; Peter E Müller
Journal:  Int Orthop       Date:  2014-07-17       Impact factor: 3.075

8.  Spaceflight and simulated microgravity suppresses macrophage development via altered RAS/ERK/NFκB and metabolic pathways.

Authors:  Lu Shi; Hongling Tian; Peng Wang; Ling Li; Zhaoqi Zhang; Jiayu Zhang; Yong Zhao
Journal:  Cell Mol Immunol       Date:  2020-01-03       Impact factor: 11.530

9.  Retracted: Evaluation by an Aeronautic Dentist on the Adverse Effects of a Six-Week Period of Microgravity on the Oral Cavity.

Authors:  International Journal Of Dentistry
Journal:  Int J Dent       Date:  2021-04-14

10.  Morphological and physiological changes in mature in vitro neuronal networks towards exposure to short-, middle- or long-term simulated microgravity.

Authors:  Giuseppe Pani; Nada Samari; Roel Quintens; Louis de Saint-Georges; Mariantonia Meloni; Sarah Baatout; Patrick Van Oostveldt; Mohammed Abderrafi Benotmane
Journal:  PLoS One       Date:  2013-09-16       Impact factor: 3.240

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