| Literature DB >> 20623998 |
Sotiria Palioura1, Johannes Herkel, Miljan Simonović, Ansgar W Lohse, Dieter Söll.
Abstract
Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.Entities:
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Year: 2010 PMID： 20623998 PMCID： PMC6644032 DOI： 10.1515/BC.2010.078
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915