| Literature DB >> 20623717 |
Firoj Ahmed1, Kazufumi Toume, Takashi Ohtsuki, Mahmudur Rahman, Samir Kumar Sadhu, Masami Ishibashi.
Abstract
Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.Entities:
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Year: 2011 PMID： 20623717 DOI： 10.1002/ptr.3219
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878