Literature DB >> 20622931

Multi-scale Modelling for Threshold Dependent Differentiation.

A Q Cai1, Y Peng, J Wells, X Dai, Q Nie.   

Abstract

The maintenance of a stable stem cell population in the epidermis is important for robust regeneration of the stratified epithelium. The population size is usually regulated by cell secreted extracellular signalling molecules as well as intracellular molecules. In this paper, a simple model incorporating both levels of regulation is developed to examine the balance between growth and differentiation for the stem cell population. In particular, the dynamics of a known differentiation regulator c-Myc, its threshold dependent differentiation, and feedback regulation on maintaining a stable stem cell population are investigated.

Entities:  

Year:  2009        PMID： 20622931      PMCID： PMC2900806          DOI： 10.1051/mmnp/20094403

Source DB:  PubMed          Journal:  Math Model Nat Phenom        ISSN： 0973-5348            Impact factor:   4.157


  19 in total

Review 1.  Getting under the skin of epidermal morphogenesis.

Authors:  Elaine Fuchs; Srikala Raghavan
Journal:  Nat Rev Genet       Date:  2002-03       Impact factor: 53.242

2.  c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation.

Authors:  Anne Wilson; Mark J Murphy; Thordur Oskarsson; Konstantinos Kaloulis; Michael D Bettess; Gabriela M Oser; Anne-Catherine Pasche; Christian Knabenhans; H Robson Macdonald; Andreas Trumpp
Journal:  Genes Dev       Date:  2004-11-15       Impact factor: 11.361

3.  T cell development in the thymus: from periodic seeding to constant output.

Authors:  Anna Q Cai; Kerry A Landman; Barry D Hughes; Colleen M Witt
Journal:  J Theor Biol       Date:  2007-08-09       Impact factor: 2.691

4.  Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum-free medium: clonal analyses, growth kinetics, and cell cycle studies.

Authors:  J J Wille; M R Pittelkow; G D Shipley; R E Scott
Journal:  J Cell Physiol       Date:  1984-10       Impact factor: 6.384

5.  c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny.

Authors:  I Arnold; F M Watt
Journal:  Curr Biol       Date:  2001-04-17       Impact factor: 10.834

6.  Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

Authors:  I P Tomlinson; W F Bodmer
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

7.  Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

Authors:  A B Glick; A B Kulkarni; T Tennenbaum; H Hennings; K C Flanders; M O'Reilly; M B Sporn; S Karlsson; S H Yuspa
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

8.  Estimation of the proliferation and maturation functions in a physiologically structured model of thymocyte development. Function estimation in thymocyte model.

Authors:  Guanyu Wang
Journal:  J Math Biol       Date:  2007-01-09       Impact factor: 2.164

9.  Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription.

Authors:  Mahalakshmi Nair; Andy Teng; Virginia Bilanchone; Anshu Agrawal; Baoan Li; Xing Dai
Journal:  J Cell Biol       Date:  2006-04-24       Impact factor: 10.539

10.  Numerical modelling of label-structured cell population growth using CFSE distribution data.

Authors:  Tatyana Luzyanina; Dirk Roose; Tim Schenkel; Martina Sester; Stephan Ehl; Andreas Meyerhans; Gennady Bocharov
Journal:  Theor Biol Med Model       Date:  2007-07-24       Impact factor: 2.432
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