Literature DB >> 20621834

Role of hepatocyte nuclear factor-4alpha in transcriptional regulation of C1qTNF-related protein 5 in the liver.

Mi-Jin Kim1, Wan Lee, Eun-Ju Park, Seung-Yoon Park.   

Abstract

Recently, we found that C1qTNF-related protein 5 (CTRP5) is involved in glucose and lipid metabolism. However, the transcriptional regulation of CTRP5 is largely unknown. Here we demonstrate the mechanism by which the CTRP5 gene is transcriptionally activated in the liver. CTRP5 is activated by HNF4alpha via the region -206/-167 of the human CTRP5 promoter. Deletion of this region significantly decreased HNF4alpha-induced CTRP5 promoter activity. Gel shift and chromatin immunoprecipitation analysis showed that HNF4alpha directly binds to HNF4alpha-responsive element at the region -202/-177 of the CTRP5 promoter. Taken together, these results show that hepatocyte nuclear factor-4alpha is involved in transcriptional regulation of CTRP5 in the liver. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20621834     DOI： 10.1016/j.febslet.2010.05.049

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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