| Literature DB >> 20621728 |
Michael B Wallace1, Mark E Adams, Toufike Kanouni, Clifford D Mol, Douglas R Dougan, Victoria A Feher, Shawn M O'Connell, Lihong Shi, Petro Halkowycz, Qing Dong.
Abstract
A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20621728 DOI： 10.1016/j.bmcl.2010.05.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823