| Literature DB >> 20621727 |
Wanyi Zhao1, Xiue Feng, Shurong Ban, Wenhan Lin, Qingshan Li.
Abstract
A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H(2)O(2))-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3'-dibromo-4,5,6'-trihydroxydiphenylmethanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H(2)O(2)-induced injury in HUVEC with EC(50) values of 0.4 and 0.8 microM, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20621727 DOI： 10.1016/j.bmcl.2010.05.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823