| Literature DB >> 20621654 |
C Belizna1, D Henrion, A Beucher, C Lavigne, A Ghaali, H Lévesque.
Abstract
Anti-Ku antibodies are reported in various connective tissue diseases and the Ku complex can be responsible for a very strong autoimmune answer in autoimmune disease. Nowadays, anti-Ku antibodies are detected by ELISA, counterimmunoelectrophoresis (CIE), immunoblot (IB) and new highly performant techniques. Although the prevalence of anti-Ku antibodies is not homogenous, depending on several features such as disease type, genetic and geographical clustering, and also method of detection, they could be found in 55% overlap PM/systemic sclerosis patients. Moreover, anti-Ku antibodies are not associated with a particular clinical outcome, and especially with cancer related to myositis. 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20621654 DOI： 10.1016/j.autrev.2010.05.020
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754