Literature DB >> 20621489

Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit.

Maja Matanović Skugor1, Vlado Stimac, Ivana Palej, Durdjica Lugarić, Hana Cipcić Paljetak, Darko Filić, Marina Modrić, Ivica Dilović, Dubravka Gembarovski, Stjepan Mutak, Vesna Eraković Haber, David J Holmes, Zrinka Ivezić-Schoenfeld, Sulejman Alihodzić.   

Abstract

The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20621489     DOI： 10.1016/j.bmc.2010.06.050

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  Macrolones Are a Novel Class of Macrolide Antibiotics Active against Key Resistant Respiratory Pathogens In Vitro and In Vivo.

Authors:  Hana Čipčić Paljetak; Donatella Verbanac; Jasna Padovan; Miroslava Dominis-Kramarić; Željko Kelnerić; Mihaela Perić; Mihailo Banjanac; Gabrijela Ergović; Nerrisa Simon; John Broskey; David J Holmes; Vesna Eraković Haber
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

2.  Two approaches to the use of benzo[c][1,2]oxaboroles as active fragments for synthetic transformation of clarithromycin.

Authors:  Gennady B Lapa; Elena P Mirchink; Elena B Isakova; Maria N Preobrazhenskaya
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051
  2 in total

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