| Literature DB >> 20621474 |
Yoshinori Takeda1, Naomi Tanigawa, Fortunatus Sunghwa, Masayuki Ninomiya, Makoto Hagiwara, Kenji Matsushita, Mamoru Koketsu.
Abstract
A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20621474 DOI： 10.1016/j.bmcl.2010.06.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823