BACKGROUND: Major depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression. METHODS: Region-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression. RESULTS: FA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory. CONCLUSIONS: Brain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression.
BACKGROUND: Major depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression. METHODS: Region-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression. RESULTS: FA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory. CONCLUSIONS: Brain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression.
Authors: L Sarro; F Agosta; E Canu; N Riva; A Prelle; M Copetti; G Riccitelli; G Comi; M Filippi Journal: AJNR Am J Neuroradiol Date: 2011-10-20 Impact factor: 3.825
Authors: Kan Ding; Takashi Tarumi; David C Zhu; Benjamin Y Tseng; Binu P Thomas; Marcel Turner; Justin Repshas; Diana R Kerwin; Kyle B Womack; Hanzhang Lu; C Munro Cullum; Rong Zhang Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: David J Madden; Ilana J Bennett; Agnieszka Burzynska; Guy G Potter; Nan-Kuei Chen; Allen W Song Journal: Biochim Biophys Acta Date: 2011-08-16
Authors: Daniel F Hermens; Sean N Hatton; Rico S C Lee; Sharon L Naismith; Shantel L Duffy; G Paul Amminger; Manreena Kaur; Elizabeth M Scott; Jim Lagopoulos; Ian B Hickie Journal: Eur Arch Psychiatry Clin Neurosci Date: 2017-03-29 Impact factor: 5.270