| Literature DB >> 20621143 |
Yanfeng Gao1, Kun Chen, Bin Zhang, Xiang Li, Lu Chen, Yuanjun Li, Xiangjiao Jia, Yongxing Lei, Zhongyi Yan, Liangliang Kong, Nan Wang, Wei Liu, Yuanming Qi.
Abstract
The extracellular death factor (EDF) is a newly discovered linear pentapeptide with the sequence of H-Asn-Asn-Trp-Asn-Asn-OH (NNWNN). It could act as a quorum-sensing molecule and participate in the mazEF-mediated cell death in Escherichia coli. In the present study, we firstly studied the antioxidant and free radical-scavenging activities of EDF. EDF could scavenge hydroxyl radicals in vitro and protect protein, lipid and DNA from being damaged by hydroxyl radicals. Our results indicated that this extracellular death factor might have dual effects during the programmed cell death process of Escherichia coli.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20621143 DOI： 10.1016/j.peptides.2010.06.034
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750