Literature DB >> 20620867

A less flexible BK channel opens more easily.

Jack Kronengold1, Leonard K Kaczmarek.   

Abstract

BK potassium channels regulate spike width and firing rate. A BK point mutation in humans enhances channel activity, leading to epilepsy. In this issue of Neuron, Yang and colleagues use this mutation to demonstrate that channel opening is determined by the flexibility of a region that contains a Ca(2+)-binding site.

Entities:  

Year:  2010        PMID： 20620867      PMCID： PMC3703916          DOI： 10.1016/j.neuron.2010.06.013

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  11 in total

1.  Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels.

Authors:  V K Gribkoff; J E Starrett; S I Dworetzky; P Hewawasam; C G Boissard; D A Cook; S W Frantz; K Heman; J R Hibbard; K Huston; G Johnson; B S Krishnan; G G Kinney; L A Lombardo; N A Meanwell; P B Molinoff; R A Myers; S L Moon; A Ortiz; L Pajor; R L Pieschl; D J Post-Munson; L J Signor; N Srinivas; M T Taber; G Thalody; J T Trojnacki; H Wiener; K Yeleswaram; S W Yeola
Journal:  Nat Med       Date:  2001-04       Impact factor: 53.440

Review 2.  Calcium-activated potassium channels: multiple contributions to neuronal function.

Authors:  E S Louise Faber; Pankaj Sah
Journal:  Neuroscientist       Date:  2003-06       Impact factor: 7.519

3.  BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.

Authors:  Robert Brenner; Qing H Chen; Alex Vilaythong; Glenn M Toney; Jeffrey L Noebels; Richard W Aldrich
Journal:  Nat Neurosci       Date:  2005-10-30       Impact factor: 24.884

Review 4.  High-conductance potassium channels of the SLO family.

Authors:  Lawrence Salkoff; Alice Butler; Gonzalo Ferreira; Celia Santi; Aguan Wei
Journal:  Nat Rev Neurosci       Date:  2006-12       Impact factor: 34.870

5.  An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.

Authors:  Junqiu Yang; Gayathri Krishnamoorthy; Akansha Saxena; Guohui Zhang; Jingyi Shi; Huanghe Yang; Kelli Delaloye; David Sept; Jianmin Cui
Journal:  Neuron       Date:  2010-06-24       Impact factor: 17.173

6.  Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder.

Authors:  Wei Du; Jocelyn F Bautista; Huanghe Yang; Ana Diez-Sampedro; Sun-Ah You; Lejin Wang; Prakash Kotagal; Hans O Lüders; Jingyi Shi; Jianmin Cui; George B Richerson; Qing K Wang
Journal:  Nat Genet       Date:  2005-06-05       Impact factor: 38.330

7.  Transplantable sites confer calcium sensitivity to BK channels.

Authors:  M Schreiber; A Yuan; L Salkoff
Journal:  Nat Neurosci       Date:  1999-05       Impact factor: 24.884

8.  BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells.

Authors:  Ning Gu; Koen Vervaeke; Johan F Storm
Journal:  J Physiol       Date:  2007-02-15       Impact factor: 5.182

9.  Anticonvulsant effects of the BK-channel antagonist paxilline.

Authors:  Jesse J Sheehan; Brett L Benedetti; Alison L Barth
Journal:  Epilepsia       Date:  2008-11-19       Impact factor: 5.864

10.  Calcium sensitivity of BK-type KCa channels determined by a separable domain.

Authors:  A Wei; C Solaro; C Lingle; L Salkoff
Journal:  Neuron       Date:  1994-09       Impact factor: 17.173
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