OBJECTIVE: Ventricular dysfunction (VD) in the context of brain death (BD) is one medical cause that may be reversed to extend the range of donors for cardiac transplant programs. The aim of this study was to identify and quantify the causes for exclusion of potential heart donors and to define risk factors for VD among the BD population. MATERIALS AND METHODS: This study of 100 heart-beating potential donors defined subjects as those younger than 50 years. We defined hemodynamic dysfunction (HD) as failure to achieve hemodynamic objectives despite the use of inotropic agents by protocol or upon diagnosing VD. RESULTS: Among 246 BD subjects were 100 potential heart donors. Of these, 75 were transformed into real donors (RD) including 13 heart RD and 62 noncardiac RD. The conversion rate of BD subjects younger than 50 years to heart RD was 17%. When we analyzed the medical reasons for exclusion of the 62 donors who were not converted to heart RD, we observed that HD was the major cause (34%). When we analyzed the causes for exclusion related to cause of death, cranial trauma predominated (52%; P = .01; relative risk 3.5; 95% confidence interval 1.4-8.5). CONCLUSION: Hemodynamic dysfunction represented the major cause for loss of heart donors; it was associated with younger patients with cranial trauma.
OBJECTIVE:Ventricular dysfunction (VD) in the context of brain death (BD) is one medical cause that may be reversed to extend the range of donors for cardiac transplant programs. The aim of this study was to identify and quantify the causes for exclusion of potential heart donors and to define risk factors for VD among the BD population. MATERIALS AND METHODS: This study of 100 heart-beating potential donors defined subjects as those younger than 50 years. We defined hemodynamic dysfunction (HD) as failure to achieve hemodynamic objectives despite the use of inotropic agents by protocol or upon diagnosing VD. RESULTS: Among 246 BD subjects were 100 potential heart donors. Of these, 75 were transformed into real donors (RD) including 13 heart RD and 62 noncardiac RD. The conversion rate of BD subjects younger than 50 years to heart RD was 17%. When we analyzed the medical reasons for exclusion of the 62 donors who were not converted to heart RD, we observed that HD was the major cause (34%). When we analyzed the causes for exclusion related to cause of death, cranial trauma predominated (52%; P = .01; relative risk 3.5; 95% confidence interval 1.4-8.5). CONCLUSION:Hemodynamic dysfunction represented the major cause for loss of heart donors; it was associated with younger patients with cranial trauma.
Authors: Xenia I Borbely; Vijay Krishnamoorthy; Shan Modi; Ali Rowhani-Rahbar; Edward Gibbons; Michael J Souter; Monica S Vavilala Journal: Neurocrit Care Date: 2015-08 Impact factor: 3.210
Authors: Judith E van Zanden; Neeltina M Jager; Mohamed R Daha; Michiel E Erasmus; Henri G D Leuvenink; Marc A Seelen Journal: Front Immunol Date: 2019-02-27 Impact factor: 7.561
Authors: Yaron D Barac; Oliver K Jawitz; Jacob Klapper; Jacob Schroder; Mani A Daneshmand; Chet Patel; Matt G Hartwig; Nancy K Sweitzer; Carmelo A Milano Journal: J Am Heart Assoc Date: 2019-08-30 Impact factor: 5.501