Literature DB >> 20620432

Platelet formation.

Jonathan N Thon1, Joseph E Italiano.   

Abstract

Thrombocytopenia is the underlying cause of a number of major clinical conditions and genetic disorders worldwide. While therapeutic agents that bind and stimulate the thrombopoietin receptor are currently available, the development of drugs that directly stimulate megakaryocytes to generate platelets has lagged behind. To improve the management of thrombocytopenia, we will need to define the cell biological pathways that drive the production of platelets from megakaryocytes. This review integrates the latest research of platelet biogenesis and focuses on the molecular pathways that power and regulate proplatelet production.

Entities:  

Mesh：

Year:  2010        PMID： 20620432      PMCID： PMC2904625          DOI： 10.1053/j.seminhematol.2010.03.005

Source DB:  PubMed          Journal:  Semin Hematol        ISSN： 0037-1963            Impact factor:   3.851


  34 in total

1.  Mechanisms of organelle transport and capture along proplatelets during platelet production.

Authors:  Jennifer L Richardson; Ramesh A Shivdasani; Chad Boers; John H Hartwig; Joseph E Italiano
Journal:  Blood       Date:  2005-08-23       Impact factor: 22.113

2.  In vitro and in vivo megakaryocyte differentiation of fresh and ex-vivo expanded cord blood cells: rapid and transient megakaryocyte reconstitution.

Authors:  Stefania Bruno; Monica Gunetti; Loretta Gammaitoni; Alessandra Danè; Giuliana Cavalloni; Fiorella Sanavio; Franca Fagioli; Massimo Aglietta; Wanda Piacibello
Journal:  Haematologica       Date:  2003-04       Impact factor: 9.941

3.  Circulating proplatelets: isolation and quantitation in healthy rats and in rats with induced acute blood loss.

Authors:  P J Handagama; B F Feldman; N C Jain; T B Farver; C S Kono
Journal:  Am J Vet Res       Date:  1987-06       Impact factor: 1.156

Review 4.  Molecular and transcriptional regulation of megakaryocyte differentiation.

Authors:  R A Shivdasani
Journal:  Stem Cells       Date:  2001       Impact factor: 6.277

5.  Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets.

Authors:  A Schmitt; J Guichard; J M Massé; N Debili; E M Cramer
Journal:  Exp Hematol       Date:  2001-11       Impact factor: 3.084

6.  Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function.

Authors:  M Gaur; T Kamata; S Wang; B Moran; S J Shattil; A D Leavitt
Journal:  J Thromb Haemost       Date:  2006-02       Impact factor: 5.824

7.  Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage.

Authors:  D N Haylock; L B To; T L Dowse; C A Juttner; P J Simmons
Journal:  Blood       Date:  1992-09-15       Impact factor: 22.113

8.  Preferential ex vivo expansion of megakaryocytes from human cord blood CD34+-enriched cells in the presence of thrombopoietin and limiting amounts of stem cell factor and Flt-3 ligand.

Authors:  Chantal Proulx; Lucie Boyer; Darin R Hurnanen; Réal Lemieux
Journal:  J Hematother Stem Cell Res       Date:  2003-04

9.  Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional.

Authors:  E S Choi; J L Nichol; M M Hokom; A C Hornkohl; P Hunt
Journal:  Blood       Date:  1995-01-15       Impact factor: 22.113

10.  Blood platelet formation in vitro. The role of the cytoskeleton in megakaryocyte fragmentation.

Authors:  F Tablin; M Castro; R M Leven
Journal:  J Cell Sci       Date:  1990-09       Impact factor: 5.285
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  48 in total

1.  High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production.

Authors:  Jonathan N Thon; Matthew T Devine; Antonija Jurak Begonja; Jay Tibbitts; Joseph E Italiano
Journal:  Blood       Date:  2012-06-04       Impact factor: 22.113

2.  Platelet mimetic particles for targeting thrombi in flowing blood.

Authors:  Nishit Doshi; Jennifer N Orje; Blanca Molins; Jeffrey W Smith; Samir Mitragotri; Zaverio M Ruggeri
Journal:  Adv Mater       Date:  2012-05-29       Impact factor: 30.849

3.  BAR proteins in cancer and blood disorders.

Authors:  Yolande Chen; Jorie Aardema; Ashish Misra; Seth J Corey
Journal:  Int J Biochem Mol Biol       Date:  2012-05-18

Review 4.  Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets.

Authors:  Xiuli Sim; Mortimer Poncz; Paul Gadue; Deborah L French
Journal:  Blood       Date:  2016-01-19       Impact factor: 22.113

Review 5.  Modeling stochastic kinetics of molecular machines at multiple levels: from molecules to modules.

Authors:  Debashish Chowdhury
Journal:  Biophys J       Date:  2013-06-04       Impact factor: 4.033

Review 6.  Platelets and the immune continuum.

Authors:  John W Semple; Joseph E Italiano; John Freedman
Journal:  Nat Rev Immunol       Date:  2011-04       Impact factor: 53.106

Review 7.  Thrombocytosis as a prognostic marker in gastrointestinal cancers.

Authors:  Ioannis A Voutsadakis
Journal:  World J Gastrointest Oncol       Date:  2014-02-15

8.  Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability.

Authors:  Christian Bächer; Markus Bender; Stephan Gekle
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-27       Impact factor: 11.205

9.  Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.

Authors:  Camelia Iancu-Rubin; David Gajzer; Goar Mosoyan; Faye Feller; John Mascarenhas; Ronald Hoffman
Journal:  Exp Hematol       Date:  2012-02-27       Impact factor: 3.084

10.  Estrogen promotes megakaryocyte polyploidization via estrogen receptor beta-mediated transcription of GATA1.

Authors:  C Du; Y Xu; K Yang; S Chen; X Wang; S Wang; C Wang; M Shen; F Chen; M Chen; D Zeng; F Li; T Wang; F Wang; J Zhao; G Ai; T Cheng; Y Su; J Wang
Journal:  Leukemia       Date:  2016-10-17       Impact factor: 11.528
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