| Literature DB >> 20620033 |
James M Stone1, Elvira Bramon, Astrid Pauls, Alex Sumich, Philip K McGuire.
Abstract
Thalamic neurochemical abnormalities may underlie psychotic symptoms and auditory event-related potential (ERP) abnormalities in schizophrenia. We investigated this hypothesis in subjects at risk of psychosis using magnetic resonance spectroscopy and electroencephalography (EEG). Reduced thalamic glutamate plus glutamine and N-acetyl aspartate levels were associated with abnormal frontal ERPs, supporting a thalamic basis for filtering impairments. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2010 PMID: 20620033 DOI: 10.1016/j.pscychresns.2010.05.004
Source DB: PubMed Journal: Psychiatry Res ISSN: 0165-1781 Impact factor: 3.222