BACKGROUND: Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association. MATERIALS AND METHODS: We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables. CONCLUSIONS: Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women.
BACKGROUND: Fruits and vegetables contain a wide variety of phytochemicals which may have anti-carcinogenic effects. Although the results of case-control studies have suggested a possible protective effect of fruit and vegetable intake on the risk of endometrial carcinoma, few cohort studies have examined this association. MATERIALS AND METHODS: We used data from the NIH-AARP Diet and Health Study to assess the association of fruit and vegetable consumption, as well as intake of specific botanical groupings of fruits and vegetables, with endometrial cancer risk among 112,088 women who completed a food-frequency questionnaire at baseline, in 1995-1996. During 8 years of follow-up 1142 incident cases of endometrial cancer were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: After adjustment for covariates, HRs for the highest compared to the lowest quintile of total fruit and total vegetable intake were 1.30 (95% CI 1.04-1.61, P for trend 0.05) and 1.09 (95% CI 0.90-1.33, P for trend 0.55), respectively. No inverse associations were observed for intake of any of 13 botanical groupings of fruits and vegetables. CONCLUSIONS: Results from this large prospective study do not support a protective role of a high intake of fruits or vegetables on the risk of endometrial cancer in older women.
Authors: A F Subar; D Midthune; M Kulldorff; C C Brown; F E Thompson; V Kipnis; A Schatzkin Journal: Am J Epidemiol Date: 2000-08-01 Impact factor: 4.897
Authors: James V Lacey; Michael F Leitzmann; Shih-Chen Chang; Traci Mouw; Albert R Hollenbeck; Arthur Schatzkin; Louise A Brinton Journal: Cancer Date: 2007-04-01 Impact factor: 6.860
Authors: Frances E Thompson; Victor Kipnis; Douglas Midthune; Laurence S Freedman; Raymond J Carroll; Amy F Subar; Charles C Brown; Matthew S Butcher; Traci Mouw; Michael Leitzmann; Arthur Schatzkin Journal: Public Health Nutr Date: 2007-07-05 Impact factor: 4.022
Authors: M Rossi; V Edefonti; M Parpinel; P Lagiou; M Franchi; M Ferraroni; A Decarli; A Zucchetto; D Serraino; L Dal Maso; E Negri; C La Vecchia Journal: Br J Cancer Date: 2013-08-06 Impact factor: 7.640